Preparation of Super Absorbent and Highly Active Fish Collagen Sponge and its Hemostatic Effect in vivo and in vitro
文献类型：期刊论文
| 作者 | Wang, Lei1,2 ; Li, Wenjun1; Qu, Yan3; Wang, Kai4; Lv, Kangning5; He, Xiaoli5; Qin, Song1
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| 刊名 | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
 |
| 出版日期 | 2022-03-10 |
| 卷号 | 10页码:14 |
| 关键词 | hemostatic material high porosity high blood absorption rate fish collagen adhesion |
| ISSN号 | 2296-4185 |
| DOI | 10.3389/fbioe.2022.862532 |
| 通讯作者 | Qin, Song(sqin@yic.ac.cn) |
| 英文摘要 | Effective control of acute wound hemorrhage caused by battlefields, car accidents, natural disasters can highly improve patients' survival rates. Nevertheless, hemostatic materials on present market have various defects and limitations. This study utilizes tilapia to extract macromolecular type I collagen to prepare a new hemostatic sponge for controlling acute wound bleeding. The extracted fish collagen has high purity, uniform molecular size and high hydroxyproline content. The peptide chain structure and natural high-level structure are intactly preserved. The infrared absorption spectrum showcases that it preserves all the characteristic absorption bands of type I collagen. The developed hemostatic sponge has a uniform honeycomb-shaped porous structure and high water absorption capacity. The biological safety test illustrates that the sponge cell has good compatibility and it will not trigger any inflammatory reaction or immune rejection reactions in the body. The sponge cell could be degraded gradually and completely, which has good biocompatibility and degradation performance. The result of in vitro experiments shows that certain groups or structures in fish collagen molecules can combine specific sites on the surface of blood cells and platelets, which can quickly activate platelets and coagulation system to obtain better coagulation function. The result of In vivo experiments further shows that the fish collagen sponge has fast coagulation speed and low bleeding during the hemostasis process of rabbit ear arteries and rat liver wounds, which proves that it has excellent coagulation performance. |
| WOS关键词 | COTTON |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000783638300001 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/31291]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 通讯作者 | Qin, Song |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Weifang Med Univ, Affiliated Hosp, Dept Dermatol, Weifang, Peoples R China 4.Qingdao Univ, Affiliated Yantai Yuhuangding Hosp, Dept Orthoped, Weifang, Peoples R China 5.Yantai Univ, Yantai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Lei,Li, Wenjun,Qu, Yan,et al. Preparation of Super Absorbent and Highly Active Fish Collagen Sponge and its Hemostatic Effect in vivo and in vitro[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2022,10:14. |
| APA | Wang, Lei.,Li, Wenjun.,Qu, Yan.,Wang, Kai.,Lv, Kangning.,...&Qin, Song.(2022).Preparation of Super Absorbent and Highly Active Fish Collagen Sponge and its Hemostatic Effect in vivo and in vitro.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,10,14. |
| MLA | Wang, Lei,et al."Preparation of Super Absorbent and Highly Active Fish Collagen Sponge and its Hemostatic Effect in vivo and in vitro".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 10(2022):14. |
入库方式： OAI收割
来源：烟台海岸带研究所
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