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Antimicrobial and Antioxidant Activities of N-2-Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Amino Acid Schiff Bases

文献类型：期刊论文

作者Cui, Jingmin1,2,3; Ji, Xia4; Mi, Yingqi1,2,3; Miao, Qin1,2,3; Dong, Fang1,3; Tan, Wenqiang1,3; Guo, Zhanyong1,2,3
刊名MARINE DRUGS
出版日期2022-02-01
卷号20期号:2页码:13
关键词N-2-hydroxypropyltrimethyl ammonium chloride chitosan amino acid Schiff bases antimicrobial activity antioxidant activity
DOI10.3390/md20020086
通讯作者Ji, Xia(jixia@qlmu.edu.cn) ; Guo, Zhanyong(zyguo@yic.ac.cn)
英文摘要N-2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC), a cationic quaternary ammonium salt polymer exhibiting good solubility in water, is widely used because of its low toxicity and good biocompatibility. Herein, through ion exchange reaction, we prepared N-2-hydroxypropyltrimethyl ammonium chitosan derivatives bearing amino acid Schiff bases with good biological activities. The accuracy of the structures was verified by FT-IR and H-1 NMR. The antibacterial activity, antifungal activity, and scavenging ability of DPPH radical and superoxide radical of HACC derivatives were significantly improved compared with that of HACC. In particular, HACGM (HACC-potassium 2-((2-hydroxy-3-methoxybenzylidene)amino)acetate) and HACGB (HACC-potassium 2-((5-bromo-2-hydroxybenzylidene)amino)acetate) showed good inhibitory effect on bacteria and fungi, including Staphylococcus aureus, Escherichia coli, Botrytis cinerea, and Fusarium oxysporum f. sp. cubense. The inhibition rate of HACGB on Staphylococcus aureus and Escherichia coli could reach 100% at the concentration of 0.1 mg/mL, and the inhibition rate of HACGM and HACGB on Botrytis cinerea and Fusarium oxysporum f. sp. cubense could also reach 100% at the concentration of 0.5 mg/mL. Improving antimicrobial and antioxidant activities of HACC could provide ideas and experiences for the development and utilization of chitosan derivatives.
WOS关键词CHLORIDE CHITOSAN ; ANTIBACTERIAL ACTIVITY ; IN-VITRO ; COMPLEXES ; CHITIN ; NANOPARTICLES ; CHALLENGES ; REMOVAL
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000765138500001
资助机构National Key Research and Development Program of China ; Ministry of Science and Technology of the People's Republic of China
源URL[http://ir.yic.ac.cn/handle/133337/31420]  
专题海岸带生物学与生物资源利用重点实验室
海岸带生物资源高效利用研究与发展中心
通讯作者Ji, Xia; Guo, Zhanyong
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
4.Qilu Med Univ, Sch Pharm, Zibo 255300, Peoples R China
推荐引用方式
GB/T 7714		 Cui, Jingmin,Ji, Xia,Mi, Yingqi,et al. Antimicrobial and Antioxidant Activities of N-2-Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Amino Acid Schiff Bases[J]. MARINE DRUGS,2022,20(2):13.
APA Cui, Jingmin.,Ji, Xia.,Mi, Yingqi.,Miao, Qin.,Dong, Fang.,...&Guo, Zhanyong.(2022).Antimicrobial and Antioxidant Activities of N-2-Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Amino Acid Schiff Bases.MARINE DRUGS,20(2),13.
MLA Cui, Jingmin,et al."Antimicrobial and Antioxidant Activities of N-2-Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Amino Acid Schiff Bases".MARINE DRUGS 20.2(2022):13.

入库方式： OAI收割

来源：烟台海岸带研究所

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