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The relationships between arsenic methylation and both skin lesions and hypertension caused by chronic exposure to arsenic in drinking water

文献类型：期刊论文

作者Wei, Binggan3; Yu, Jiangping3; Wang, Jing1,3; Yang, Linsheng1,3; Li, Hairong1,3; Kong, Chang1,3; Xia, Yajuan2; Wu, Kegong2
刊名ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
出版日期2017-07-01
卷号53页码:89-94
关键词Arsenic Methylation Skin lesions Hypertension Drinking water
ISSN号1382-6689
DOI10.1016/j.etap.2017.05.009
通讯作者Yang, Linsheng(yangls@igsnrr.ac.cn) ; Li, Hairong(lihr@igsnrr.ac.cn)
英文摘要The associations between arsenic exposure, arsenic methylation, and the prevalence of skin lesions and hypertension are investigated. The results indicate that the HS (hypertension and skin lesions) group and the S (skin lesions) group have higher urinary concentrations of iAs (inorganic arsenic), MMA (monomethylarsonic acid), DMA (dimethylarsinous acid) and%MMA, and lower SMI (secondary arsenic methylation index) compared to the H (hypertension) and N (without both hypertension and skin lesions) groups. The arsenic content in water which caused H may be lower than that which caused HS and S. In addition, the odds ratios suggest that higher urinary concentrations of iAs and MMA, %iAs, %MMA and PMI elevate the prevalence of only hypertension and skin lesions, and both hypertension and skin lesions. However, higher%DMA and SMI, and lower%MMA increase the prevalence of both hypertension and skin lesions compared to that of only skin lesions. It can be concluded that skin lesions subjects have higher prevalence of hypertension. Hypertension subjects may have higher prevalence of skin lesions. Lower%DMA and SMI, higher%iAs, %MMA and PMI enhance the prevalence of only hypertension and skin lesions, and both hypertension and skin lesions. Moreover, iAs and MMA may have higher toxicity and lead to both hypertension and skin lesions than to only hypertension.
WOS关键词INNER-MONGOLIA ; BLOOD-PRESSURE ; NORTHERN CHINA ; CAPACITY ; METABOLITES ; AREA ; INDIVIDUALS ; ASSOCIATION ; TAIWAN ; COHORT
资助项目State Key Program of National Natural Science of China[41230749] ; National Natural Science of China[41601559]
WOS研究方向Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
语种英语
WOS记录号WOS:000406566200012
出版者ELSEVIER SCIENCE BV
资助机构State Key Program of National Natural Science of China ; National Natural Science of China
源URL[http://ir.igsnrr.ac.cn/handle/311030/61483]  
专题中国科学院地理科学与资源研究所
通讯作者Yang, Linsheng; Li, Hairong
作者单位1.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing, Peoples R China
2.Inner Mongolia Ctr Endem Dis Control & Res, Hohhot, Inner Mongolia, Peoples R China
3.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Key Lab Land Surface Pattern & Simulat, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Wei, Binggan,Yu, Jiangping,Wang, Jing,et al. The relationships between arsenic methylation and both skin lesions and hypertension caused by chronic exposure to arsenic in drinking water[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2017,53:89-94.
APA Wei, Binggan.,Yu, Jiangping.,Wang, Jing.,Yang, Linsheng.,Li, Hairong.,...&Wu, Kegong.(2017).The relationships between arsenic methylation and both skin lesions and hypertension caused by chronic exposure to arsenic in drinking water.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,53,89-94.
MLA Wei, Binggan,et al."The relationships between arsenic methylation and both skin lesions and hypertension caused by chronic exposure to arsenic in drinking water".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 53(2017):89-94.

入库方式： OAI收割

来源：地理科学与资源研究所

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