Trace Element Levels in Scalp Hair of School Children in Shigatse, Tibet, an Endemic Area for Kaschin-Beck Disease (KBD)
文献类型：期刊论文
| 作者 | Guo, Ya'nan1,2; Li, Hairong1,2 ; Yang, Linsheng1,2; Li, Yonghua2; Wei, Binggan2; Wang, Wuyi2; Gong, Hongqiang3; Guo, Min3; Nima, Cangjue3; Zhao, Shengcheng3
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| 刊名 | BIOLOGICAL TRACE ELEMENT RESEARCH
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| 出版日期 | 2017-11-01 |
| 卷号 | 180期号:1页码:15-22 |
| 关键词 | Scalp hair Trace elements Kaschin-Beck disease Tibet Selenium Zinc Linear discriminant analysis |
| ISSN号 | 0163-4984 |
| DOI | 10.1007/s12011-017-0988-0 |
| 通讯作者 | Li, Hairong(lihr@igsnrr.ac.cn) |
| 英文摘要 | Kaschin-Beck disease (KBD) is an endemic osteoarthritis, and the etiology is closely related with levels of trace elements in the human body. Currently, it is clear that the selenium (Se) status of children in KBD areas is lower than that in non-KBD areas in the Tibetan Plateau, whereas role of other elements are yet unknown. This study aimed to assess some essential trace elements (Se, Mo, Mn, Zn, Fe, Cu, Co, and Sr) in children using scalp hair as a biomarker, and 157 samples from school children aged 8-14 years old were collected from both KBD and non-KBD areas in Shigatse, Tibet. Se and Mo were measured by inductive coupled plasma mass spectrometry, and the other elements were determined by inductive coupled plasma optical emission spectrometry. Compared with the non-KBD areas, Se, Mo, Mn, Fe, Zn, Co, and Sr levels of children in KBD areas were found to be significantly different (P < 0.05); while in linear discriminant analysis, only Se and Zn were found to contribute to the KBD prevalence in the study area. The hair Se level of children in KBD areas ranged from 0.115 to 0.299 mg/kg, while in non-KBD areas it ranged from 0.135 to 0.519 mg/kg. The Zn content of children's hair was between 83 and 207 mg/kg in KBD areas, while it was 37 and 219 mg/kg in non-KBD areas. Lower Se and higher Zn levels in children in KBD areas was found when compared with non-KBD groups. In addition, Mo levels were found to be different between KBD areas and non-KBD areas on the opposite side of the Yarlung Zangbo River, but no close relationship was shown because there was no difference compared with the non-KBD area on the same side of the river. Our observations suggest that Se deficiency is still an important factor for the occurrence and prevalence of KBD, while the relationship between Zn and KBD needs to be further explored in the Tibetan Plateau. |
| WOS关键词 | SELENIUM LEVELS ; CHINA ; PROVINCE ; PLATEAU ; COUNTY ; HEALTH |
| 资助项目 | National 12th Five-Year Plan scientific and technological issues of China[2013BAC04B03] ; National Natural Science Foundation of China[41671500] ; National Natural Science Foundation of China[41171081] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000411692600003 |
| 出版者 | HUMANA PRESS INC |
| 资助机构 | National 12th Five-Year Plan scientific and technological issues of China ; National Natural Science Foundation of China |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/62235]  |
| 专题 | 中国科学院地理科学与资源研究所 |
| 通讯作者 | Li, Hairong |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Key Lab Land Surface Pattern & Simulat, Beijing 100101, Peoples R China 3.Tibet Autonomous Reg Ctr Dis Control & Prevent, Inst Endem Dis Control, Lhasa 850000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Ya'nan,Li, Hairong,Yang, Linsheng,et al. Trace Element Levels in Scalp Hair of School Children in Shigatse, Tibet, an Endemic Area for Kaschin-Beck Disease (KBD)[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2017,180(1):15-22. |
| APA | Guo, Ya'nan.,Li, Hairong.,Yang, Linsheng.,Li, Yonghua.,Wei, Binggan.,...&Wang, Jing.(2017).Trace Element Levels in Scalp Hair of School Children in Shigatse, Tibet, an Endemic Area for Kaschin-Beck Disease (KBD).BIOLOGICAL TRACE ELEMENT RESEARCH,180(1),15-22. |
| MLA | Guo, Ya'nan,et al."Trace Element Levels in Scalp Hair of School Children in Shigatse, Tibet, an Endemic Area for Kaschin-Beck Disease (KBD)".BIOLOGICAL TRACE ELEMENT RESEARCH 180.1(2017):15-22. |
入库方式： OAI收割
来源：地理科学与资源研究所
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