Quinotine alkaloids with anti-inflammatory activity from Zanthoxylum avicennae
文献类型：期刊论文
| 作者 | Ji, Kai-Long1,2; Liu, Wei1,2; Yin, Wei-Hang1,2; Li, Jing-Ya1,2 ; Yue, Jian-Min1,2
|
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2022-05-10 |
| 页码 | 7 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/d2ob00711h |
| 通讯作者 | Li, Jing-Ya(jyli@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Zanthoxylum avicennae fruits were traditionally used to treat many inflammatory-related diseases, such as icterohepatitis, nephritis and colitis, which inspired us to explore the active chemicals and pharmacological activity. As a result, ten quinoline alkaloids, including six new ones, avicenines A-F (1-6), were isolated and structurally characterized by solid data. Compounds 1, 7 and 8 were identified as three pairs of enantiomers by chiral HPLC separation, of which 1 was an unusual 6/6/5/5-fused quinoline alkaloid bearing a unique cis-hexahydrofuro[3,2-b]furan moiety. The putative biosynthetic pathway for enantiomeric compounds was also proposed. In addition, compound 6 significantly suppressed the gene expression and secretion of pro-inflammatory cytokines IL-1 beta and IL-6 in macrophages. |
| WOS关键词 | HEPATOCELLULAR-CARCINOMA CELLS ; PHOSPHATASE 2A ACTIVATION ; IN-VITRO ; DERIVATIVES ; CONSTITUENTS ; COUMARIN ; INHIBIT ; EXTRACT ; BARK |
| 资助项目 | National Natural Science Foundation[22177121] ; National Natural Science Foundation[92057116] ; Science and Technology Commission of Shanghai Municipality[20ZR1467800] ; Science and Technology Commission of Shanghai Municipality[19431908100] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000792636600001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300971]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Jing-Ya; Yue, Jian-Min |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Kai-Long,Liu, Wei,Yin, Wei-Hang,et al. Quinotine alkaloids with anti-inflammatory activity from Zanthoxylum avicennae[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2022:7. |
| APA | Ji, Kai-Long,Liu, Wei,Yin, Wei-Hang,Li, Jing-Ya,&Yue, Jian-Min.(2022).Quinotine alkaloids with anti-inflammatory activity from Zanthoxylum avicennae.ORGANIC & BIOMOLECULAR CHEMISTRY,7. |
| MLA | Ji, Kai-Long,et al."Quinotine alkaloids with anti-inflammatory activity from Zanthoxylum avicennae".ORGANIC & BIOMOLECULAR CHEMISTRY (2022):7. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。