Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXII. Structurally diverse diterpenoids from the leaves and twigs of the endangered conifer Torreya jackii and their bioactivities
文献类型：期刊论文
| 作者 | Li, Hao3,4; Tang, Yu3; Liang, Kai-Yuan3,4; Zang, Yi2 ; Osman, Ezzat E. A.1,3; Jin, Ze-Xin4; Li, Jia2; Xiong, Juan3; Li, Junmin4; Hu, Jin-Feng3,4
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2022-06-01 |
| 卷号 | 198页码:9 |
| ISSN号 | 0031-9422 |
| 关键词 | Torreya jackii Taxaceae Rare and endangered plants (REPs) Torreyins Diterpenoids Acetyl-coenzyme A carboxylase 1 (ACC1) Protein tyrosine phosphatase 1B (PTP1B) 11 12-Seco-abietane |
| DOI | 10.1016/j.phytochem.2022.113161 |
| 通讯作者 | Xiong, Juan(jxiong@fudan.edu.cn) ; Li, Junmin(lijm@tzc.edu.cn) ; Hu, Jin-Feng(jfhu@tzc.edu.cn) |
| 英文摘要 | A phytochemical investigation on the MeOH extract of the leaves and twigs of the endangered conifer Torreya jackii Chun led to the isolation and characterization of 21 structurally diverse diterpenoids. Among them, six are previously undescribed, including four abietane-type (torreyins A-D, resp.) and two labdane-type diterpenoids (torreyins E and F). Their structures and absolute configurations were determined by a combination of spectroscopic methods, calculated/experimental electronic circular dichroism (ECD) data, and single-crystal X-ray diffraction analyses. In particular, torreyins A-C are rare 11,12-seco-abietane type diterpenoids possessing a dilactone moiety, and their biosynthetic pathway starting from a co-occurring abietane derivative (i.e., cyrtophyllone B) was briefly proposed. Among the isolates, 7-oxo-dehydroabietic acid and 15-methoxy-7,13-abietadien-18-oic acid showed considerable inhibitory effects against acetyl-coenzyme A carboxylase 1 (ACC1) and protein tyrosine phosphatase 1 B (PTP1B), with IC50 values of 3.1 and 6.8 mu M, respectively. |
| WOS关键词 | COMPLETE CHLOROPLAST GENOME ; ABIETANE DITERPENOIDS ; SALVIA-MILTIORRHIZA ; NATURAL-PRODUCTS ; NUCIFERA ; TAXACEAE ; ROOTS ; CONSTITUENTS ; LABDANE ; MIGRATION |
| 资助项目 | NSFC[21937002] ; NSFC[81773599] ; NSFC[21772025] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000791302400002 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300977]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xiong, Juan; Li, Junmin; Hu, Jin-Feng |
| 作者单位 | 1.Theodor Bilharz Res Inst, Dept Biochem Mol Biol & Med Chem, POB 30 Imbaba, Giza 12411, Egypt 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 4.Taizhou Univ, Sch Pharmaceut Sci, Inst Nat Med & Hlth Prod, Zhejiang Prov Key Lab Plant Ecol & Conservat, Taizhou 318000, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Li, Hao,Tang, Yu,Liang, Kai-Yuan,et al. Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXII. Structurally diverse diterpenoids from the leaves and twigs of the endangered conifer Torreya jackii and their bioactivities [J]. PHYTOCHEMISTRY,2022,198:9. |
| APA |
Li, Hao.,Tang, Yu.,Liang, Kai-Yuan.,Zang, Yi.,Osman, Ezzat E. A..,...&Hu, Jin-Feng.(2022). Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXII. Structurally diverse diterpenoids from the leaves and twigs of the endangered conifer Torreya jackii and their bioactivities .PHYTOCHEMISTRY,198,9. |
| MLA |
Li, Hao,et al." Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXII. Structurally diverse diterpenoids from the leaves and twigs of the endangered conifer Torreya jackii and their bioactivities ".PHYTOCHEMISTRY 198(2022):9. |
入库方式： OAI收割
来源：上海药物研究所
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