Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis
文献类型：期刊论文
| 作者 | Xie, Zuoquan2 ; Tong, Siyu1; Chu, Xingkun1; Feng, Teng1; Geng, Meiyu2
|
| 刊名 | KIDNEY DISEASES
 |
| 出版日期 | 2022-05-03 |
| 页码 | 11 |
| 关键词 | Kidney-brain axis Cognitive impairment Mechanism Treatment |
| ISSN号 | 2296-9381 |
| DOI | 10.1159/000524475 |
| 通讯作者 | Feng, Teng(fengteng@greenvalleypharma.com) ; Geng, Meiyu(mygeng@simm.ac.cn) |
| 英文摘要 | Background: Cognitive impairment, increasingly recognized as a major social burden, is commonly found in chronic kidney disease (CKD) patients. Summary: Vascular damage, uremic toxicity, oxidative stress, and peripheral/central inflammation induced by CKD might be involved in brain lesions and ultimately result in cognitive decline. Uncovering the pathophysiology of CKD-associated cognitive impairment is important for early diagnosis and prevention, which undoubtedly prompts innovative pharmacological treatments. Key Messages: Here, we sequentially review the current understanding and advances in the epidemiology, risk factors, and pathological mechanisms of cognitive impairment in CKD. Furthermore, we summarize the currently available therapeutic strategies for cognitive impairment in CKD. |
| WOS研究方向 | Urology & Nephrology |
| 语种 | 英语 |
| WOS记录号 | WOS:000793485700001 |
| 出版者 | KARGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300998]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Feng, Teng; Geng, Meiyu |
| 作者单位 | 1.Green Valley Shanghai Pharmaceut Co Ltd, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Zuoquan,Tong, Siyu,Chu, Xingkun,et al. Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis[J]. KIDNEY DISEASES,2022:11. |
| APA | Xie, Zuoquan,Tong, Siyu,Chu, Xingkun,Feng, Teng,&Geng, Meiyu.(2022).Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis.KIDNEY DISEASES,11. |
| MLA | Xie, Zuoquan,et al."Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis".KIDNEY DISEASES (2022):11. |
入库方式： OAI收割
来源：上海药物研究所
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