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Sulfated galactoglucan impedes xenografted lung cancer cell growth by blocking angiogenesis via binding BMPRs

文献类型：期刊论文

作者Huang, Lulin4,5; Zeng, Hui4,5; Jin, Can3,5; Ma, Xiaonan4,5; Zhang, Yiwen2,5; Huang, Chunfan3,5; Du, Zhenyun5; Ding, Kan1,2,3,4,5
刊名CARBOHYDRATE POLYMERS
出版日期2022-08-01
卷号289页码:11
关键词Sulfated polysaccharide Galactoglucan BMPR VEGF Smad Lung cancer
ISSN号0144-8617
DOI10.1016/j.carbpol.2022.119412
通讯作者Ding, Kan(dingkan@simm.ac.cn)
英文摘要Evidences propound tumor growth may be impeded by blocking angiogenesis. Before we showed that sulfated glucan or arabinogalactan might bind to BMP2 or its receptors to inhibit angiogenesis. Whether sulfated galactoglucan can target both BMPRIA and BMPRII to impede angiogenesis and tumor cells growth is still vague. Here, we prepare galactoglucan and its sulfated derivatives Sul-CDA-0.05. The sulfate groups substituted are at the C-6 of 1, 4-linked alpha-Glcp and 1, 4-linked alpha-Galp backbone and at the C-6 of branch chain T-linked alpha-Glcp. SulCDA-0.05 can inhibit angiogenesis in vitro and in vivo. Indeed, Sul-CDA-0.05 impedes xenografted A549 lung tumor cells growth. Mechanism study demonstrates that this polysaccharide may target both BMPRIA and BMPRII to block BMP/Smad/Id1 signaling and attenuate VEGF and its transcription factor. Our evidences suggest that Sul-CDA-0.05 may be a new drug candidate for anti-lung cancer therapy by targeting both BMPRIA and BMPRII.
WOS关键词INHIBITS ANGIOGENESIS ; POLYSACCHARIDE ; HIF-1
资助项目Shanghai Municipal Science and Technology Major Project, Key New Drug Creation and Manufacturing Program[2019ZX09735001] ; National Key R&D Program, Ministry of Science and Technology of People's Republic of China[2019YFC1711-000]
WOS研究方向Chemistry ; Polymer Science
语种英语
WOS记录号WOS:000792905000005
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/301012]  
专题中国科学院上海药物研究所
通讯作者Ding, Kan
作者单位1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai 201203, Peoples R China
3.Nanjing Univ Chinese Med, Coll Pharm, 138 Xianlin Ave, Nanjing, Jiangsu, Peoples R China
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Lulin,Zeng, Hui,Jin, Can,et al. Sulfated galactoglucan impedes xenografted lung cancer cell growth by blocking angiogenesis via binding BMPRs[J]. CARBOHYDRATE POLYMERS,2022,289:11.
APA Huang, Lulin.,Zeng, Hui.,Jin, Can.,Ma, Xiaonan.,Zhang, Yiwen.,...&Ding, Kan.(2022).Sulfated galactoglucan impedes xenografted lung cancer cell growth by blocking angiogenesis via binding BMPRs.CARBOHYDRATE POLYMERS,289,11.
MLA Huang, Lulin,et al."Sulfated galactoglucan impedes xenografted lung cancer cell growth by blocking angiogenesis via binding BMPRs".CARBOHYDRATE POLYMERS 289(2022):11.

入库方式： OAI收割

来源：上海药物研究所

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