Association between Metabolic Dysfunction-associated Fatty Liver Disease and Cognitive Impairment
文献类型：期刊论文
| 作者 | Yu, Qiang5; He, Ruixin3,4; Jiang, Haowen2; Wu, Ji5; Xi, Zhifeng5; He, Kang5; Liu, Yongbo5; Zhou, Tao5; Feng, Mingxuan5; Wan, Ping5 |
| 刊名 | JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
 |
| 出版日期 | 2022-02-17 |
| 页码 | 8 |
| ISSN号 | 2225-0719 |
| 关键词 | NHANES Metabolic dysfunction-associated fatty liver disease Nonalcoholic fatty liver disease Cognitive dysfunction |
| DOI | 10.14218/JCTH.2021.00490 |
| 通讯作者 | Yu, Qiang(xiaqiang@shsmu.edu.cn) ; Yan, Hexin(hexinyw@163.com) ; Xia, Qiang() |
| 英文摘要 | Background and Aims: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly proposed term based on modified criteria. Although nonalcoholic fatty liver disease (NAFLD) has been well-documented as a multisystem disease, research on the correlation of MAFLD and extra hepatic diseases is limited. This study aimed to clarify the association of MAFLD, as well as NAFLD status with cognitive function. Methods: A total of 5,662 participants 20-59 years of age who underwent cognitive tests and liver ultrasonography in the Third National Health and Nutrition Examination Survey were included in the analysis. Cognitive function was evaluated using three computer-administered tests, the serial digit learning test (SDLT), the simple reaction time test (SRTT) and the symbol digit substitution test (SDST). Results: Participants with MAFLD had significantly poorer performance on the SRTT [odds ratio (OR) 1.47, 95% confidence interval (CI): 1.14-1.89)]. MAFLD with moderate-severe liver steatosis was associated with higher risks of scoring low in the SDLT (OR 1.37, 95% CI: 1.04-1.82) and SRTT (OR 1.55, 95% CI: 1.19-2.02). NAFLD combined with metabolic dysfunction, instead of NAFLD without metabolic disorders, was associated an increased risk of a low SRTT score (OR 1.44, 95% CI: 1.10-1.82). MAFLD patients had a high probability of fibrosis, prediabetes, and diabetes and were also significantly associated with increased risks based on the SDST or SRTT score. Conclusions: MAFLD was significantly associated with increased risk of cognitive impairment, especially among MAFLD patients with a high degree of liver fibrosis, moderate-severe steatosis, or hyperglycemia. |
| WOS关键词 | EPIDEMIOLOGY ; ELASTOGRAPHY ; INFLAMMATION ; FIBROSIS ; MODEL ; RISK |
| 资助项目 | National Natural Science Foun-dation of China[32000525] ; Shanghai Mu-nicipal Science and Technology Major Project[TM202101H011] |
| WOS研究方向 | Gastroenterology & Hepatology |
| 语种 | 英语 |
| 出版者 | XIA & HE PUBLISHING INC |
| WOS记录号 | WOS:000792956300001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301018]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yu, Qiang; Yan, Hexin; Xia, Qiang |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Anesthesiol & Crit Care Med, 160 Pujian Rd, Shanghai 200127, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp,Key Lab Endocrine & Metab Dis Natl Hl, Shanghai Natl Ctr Translat Med,Shanghai Natl Clin, Shanghai, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis,Dept Endocrin, Shanghai 200127, Peoples R China 5.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Liver Surg, 160 Pujian Rd, Shanghai 200127, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Qiang,He, Ruixin,Jiang, Haowen,et al. Association between Metabolic Dysfunction-associated Fatty Liver Disease and Cognitive Impairment[J]. JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY,2022:8. |
| APA | Yu, Qiang.,He, Ruixin.,Jiang, Haowen.,Wu, Ji.,Xi, Zhifeng.,...&Xia, Qiang.(2022).Association between Metabolic Dysfunction-associated Fatty Liver Disease and Cognitive Impairment.JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY,8. |
| MLA | Yu, Qiang,et al."Association between Metabolic Dysfunction-associated Fatty Liver Disease and Cognitive Impairment".JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY (2022):8. |
入库方式： OAI收割
来源：上海药物研究所
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