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Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes via Ruthenium(II)-Catalyzed C-H Alkenylation/Directing Group Migration

文献类型：期刊论文

作者Mao, Hui4; Chen, Jing3; Zhang, Xiaoning2; Yu, Na3; Lu, Yangbin2; Zhao, Fei1,2
刊名CHEMISTRYSELECT
出版日期2022-05-13
卷号7期号:18页码:7
关键词C-H activation cascade reaction directing group migration ruthenium tetrasubstituted alkene
ISSN号2365-6549
DOI10.1002/slct.202200292
通讯作者Mao, Hui(maohui1988@126.com) ; Lu, Yangbin(lybdongyang@163.com) ; Zhao, Fei(zhaofei@cdu.edu.cn)
英文摘要Herein we report the regio- and stereoselective synthesis of tetrasubstituted alkenes from N-carbamoyl indoles and alkynes via ruthenium(II)-catalyzed C-H alkenylation/directing group migration, in which the carbamoyl directing group is endowed with a dual role of auxiliary group and migrating acylation reagent via C-N bond cleavage. This method features broad substrate scope, high atom- and step-economy, good functional group tolerance and mild redox-neutral conditions at room temperature. A series of structurally diverse tetrasubstituted alkenes were synthesized in good to excellent yields, highlighting the efficiency of this method.
WOS关键词CATALYZED HYDROARYLATION ; DIVERGENT SYNTHESIS ; BOND ACTIVATION ; DIRECTING GROUP ; N BOND ; ALKYNES ; CONSTRUCTION ; OLEFINATION ; DIVERSITY ; ACETYLIDE
资助项目Zhejiang Provincial Natural Science Foundation of China[LQ19B020003] ; Zhejiang Provincial Natural Science Foundation of China[LY21B020003] ; Jinhua Science and Technology Bureau[2021-3-150] ; Natural Science Foundation of Ningxia Province[2021AAC03389] ; State Key Laboratory of Drug Research[SIMM2105KF-09] ; Jinhua Branch of Sichuan Industrial Institute of Antibiotics[SIIAJH-202002] ; Jinhua Branch of Sichuan Industrial Institute of Antibiotics[SIIAJH-202006]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000792595700001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/301021]  
专题新药研究国家重点实验室
通讯作者Mao, Hui; Lu, Yangbin; Zhao, Fei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
2.Chengdu Univ, Sch Pharm, Jinhua Branch, Sichuan Ind Inst Antibiot, 888 West Hai Tang Rd, Jinhua 321007, Zhejiang, Peoples R China
3.Ningxia Med Univ, Gen Hosp, Dept Preparat Ctr, Yinchuan 750004, Ningxia, Peoples R China
4.Jinhua Polytech, Coll Pharm, 888 West Hai Tang Rd, Jinhua 321007, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Mao, Hui,Chen, Jing,Zhang, Xiaoning,et al. Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes via Ruthenium(II)-Catalyzed C-H Alkenylation/Directing Group Migration[J]. CHEMISTRYSELECT,2022,7(18):7.
APA Mao, Hui,Chen, Jing,Zhang, Xiaoning,Yu, Na,Lu, Yangbin,&Zhao, Fei.(2022).Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes via Ruthenium(II)-Catalyzed C-H Alkenylation/Directing Group Migration.CHEMISTRYSELECT,7(18),7.
MLA Mao, Hui,et al."Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes via Ruthenium(II)-Catalyzed C-H Alkenylation/Directing Group Migration".CHEMISTRYSELECT 7.18(2022):7.

入库方式： OAI收割

来源：上海药物研究所

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