Uncommon eunicellin-based diterpenoid and 9, 11-secosteroid from the Sanya soft coral Cladiella krempfi: Structure and stereochemistry
文献类型：期刊论文
| 作者 | Lin, Na3,4; Zhang, Meng-Meng3; Jiang, Cheng-Shi1; Li, Jia3 ; Wang, Hong4; Shen, Yi-Ran3; Guo, Yue-Wei2,3,4
|
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2022-04-13 |
| 卷号 | 95页码:5 |
| 关键词 | Soft coral
Cladiella krempfi
Eunicellin
11-secosteroid
9, 11-secosteroid 9, 11-secosteroid |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2022.153719 |
| 通讯作者 | Wang, Hong() ; Guo, Yue-Wei() |
| 英文摘要 | Two new compounds, namely an uncommon eunicellin-based diterpenoid (clakrefielin A, 2) and a 9, 11secosteroid (cladiellasterol A, 4), along with a known carotenoid (all-trans-peridinin, 7), were isolated from the Ximao Island, Sanya Bay soft coral Cladiella krempfi. The structures of these compounds were established on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, chemical transformations, as well as the comparison with the reported data in the literature. The biological activities of these compounds were investigated, and compound 7 was found to be a new protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50 = 7.2 lM). (C)& nbsp;2022 Elsevier Ltd. All rights reserved. |
| 资助项目 | Natural Science Foun-dation of China[81991521] ; SKLDR/SIMM Project[SIMM2103ZZ-06] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000792912100012 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301035]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Hong; Guo, Yue-Wei |
| 作者单位 | 1.Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Drug Discovery Shandong Lab, Yantai 264117, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 4.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Lin, Na,Zhang, Meng-Meng,Jiang, Cheng-Shi,et al. Uncommon eunicellin-based diterpenoid and 9, 11-secosteroid from the Sanya soft coral Cladiella krempfi: Structure and stereochemistry [J]. TETRAHEDRON LETTERS,2022,95:5. |
| APA |
Lin, Na.,Zhang, Meng-Meng.,Jiang, Cheng-Shi.,Li, Jia.,Wang, Hong.,...&Guo, Yue-Wei.(2022). Uncommon eunicellin-based diterpenoid and 9, 11-secosteroid from the Sanya soft coral Cladiella krempfi: Structure and stereochemistry .TETRAHEDRON LETTERS,95,5. |
| MLA |
Lin, Na,et al." Uncommon eunicellin-based diterpenoid and 9, 11-secosteroid from the Sanya soft coral Cladiella krempfi: Structure and stereochemistry ".TETRAHEDRON LETTERS 95(2022):5. |
入库方式： OAI收割
来源：上海药物研究所
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