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Chemical Constituents of Sinularia nanolobata from the South China Sea

文献类型：期刊论文

作者Zeng Zirong2,3; Zhang Mengmeng2; Wang Hong3; Li Jia2; Guo Yuewei1,2,3; Su Mingzhi1
刊名CHINESE JOURNAL OF ORGANIC CHEMISTRY
出版日期2022-03-01
卷号42期号:3页码:891-895
关键词south china sea: Sinularia nanolobata prenylelemane-type diterpene protein tyrosine phosphatase-1B (PTPIB) inhibitory activity
ISSN号0253-2786
DOI10.6023/cjoc202109004
通讯作者Guo Yuewei(ywguo@simm.ac.cn) ; Su Mingzhi(smz0310@163.com)
英文摘要A new prenylelemane-type diterpenoid named lobatate (1), together with nine known compounds, namely (17R)-loba-8,10,13(15)-triene-17,18-diol (2), alpha-tocopherolquinone (3), (1E,3Z,7E,11R,12R)-11-hydroxy-12-methoxy-1-isopropyl- 4,8,12-trimethyl-cyclotetradeca-1,3,7-triene (4), (+)-(1E,3E,7E,11R,12S)-11,12-epoxy-11,12-dihydrocembrene-C (5), (1E,3E, 7R,8S,11E)-7,8-epoxy-1-isopropyl-4,8,12-trimethyl-cyclotetradeca-1,3,11-triene (6), 24-methylene-cholesterol (7), pregnenolone (8), 3 beta,6 alpha,11-trihydroxy-24-methylene-9,11-seco-5 alpha-cholest-7-en-9-one (9), sinugrandisterol A (10), was isolated from the soft coral Sinularia nanolobata, which were collected from the Ximao Island, Sanya, South China Sea. Their structures were elucidated using comprehensive spectroscopic methods. The biological activity experiment result showed that compound 3 significantly inhibited the enzymatic activity of protein tyrosine phosphatase-1B (PTP1B) with the IC50 value of (4.83 +/- 2.35) mu mol/L. The result indicated that compound 3 has a promising potential on the drug discovery of anti-diabetes and antiobesity.
WOS关键词LOBANE ; DITERPENOIDS
资助项目National Key Research and Development Program[2018YFC0310903] ; National Natural Science Foundation of China[81991521] ; Project of State Key Laboratory of Drug Research/Shanghai Institute of Materia Medica[SIMM2103ZZ-06] ; Zhejiang Province Ten Thousand Talents Program Science and Technology Innovation Leading Talent Project[2019R52009]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000793451300021
出版者SCIENCE PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/301053]  
专题新药研究国家重点实验室
通讯作者Guo Yuewei; Su Mingzhi
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Yantai 264000, Shandong, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab New Drug Res, Shanghai 201203, Peoples R China
3.Zhejiang Univ Technol, Yangtze River Delta Green Pharmaceut Collaborat C, Hangzhou 310014, Peoples R China
推荐引用方式
GB/T 7714		 Zeng Zirong,Zhang Mengmeng,Wang Hong,et al. Chemical Constituents of Sinularia nanolobata from the South China Sea[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2022,42(3):891-895.
APA Zeng Zirong,Zhang Mengmeng,Wang Hong,Li Jia,Guo Yuewei,&Su Mingzhi.(2022).Chemical Constituents of Sinularia nanolobata from the South China Sea.CHINESE JOURNAL OF ORGANIC CHEMISTRY,42(3),891-895.
MLA Zeng Zirong,et al."Chemical Constituents of Sinularia nanolobata from the South China Sea".CHINESE JOURNAL OF ORGANIC CHEMISTRY 42.3(2022):891-895.

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来源：上海药物研究所

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