Functionalized styrene synthesis via palladium-catalyzed C-C cleavage of aryl ketones
文献类型：期刊论文
| 作者 | Zhang, Xu3; Wang, Zhen-Yu3; Wang, Xing2; Xu, Hui2; Dai, Hui-Xiong1,2,3
|
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2022-04-13 |
| 卷号 | 95页码:4 |
| 关键词 | Styrene Ligand-promoted C-C cleavage Orthogonal Suzuki-Miyaura coupling |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2022.153721 |
| 通讯作者 | Xu, Hui(xuhui2018@simm.ac.cn) ; Dai, Hui-Xiong(hxdai@simm.ac.cn) |
| 英文摘要 | We report herein the synthesis of functionalized styrenes via palladium-catalyzed Suzuki-Miyaura cross-coupling reaction between aryl ketone derivatives and potassium vinyltrifluoroborate. The employment of pyridine-oxazoline ligand was the key to the cleavage of unstrained C-C bond. A variety of functional groups and biologically important moleculars were well tolerated. The orthogonal Suzuki-Miyaura cou-pling demonstrated the synthetic practicability.(c) 2022 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CROSS-COUPLING REACTIONS ; SINGLE BOND-CLEAVAGE ; HECK REACTION ; DIRECTED CLEAVAGE ; VINYLATION ; ALKENES ; DIFUNCTIONALIZATION ; PROTOCOL ; HALIDES ; DESIGN |
| 资助项目 | Shanghai Institute of Materia Medica ; Chinese Academy of Sciences ; NSFC[21772211] ; NSFC[21920102003] ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Science and Technology Commission of Shanghai Municipality[21ZR1475400] ; Science and Technology Commission of Shanghai Municipality[18431907100] ; Program of Shanghai Academic Research Leader[19XD1424600] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000792912100013 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301062]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xu, Hui; Dai, Hui-Xiong |
| 作者单位 | 1.Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xu,Wang, Zhen-Yu,Wang, Xing,et al. Functionalized styrene synthesis via palladium-catalyzed C-C cleavage of aryl ketones[J]. TETRAHEDRON LETTERS,2022,95:4. |
| APA | Zhang, Xu,Wang, Zhen-Yu,Wang, Xing,Xu, Hui,&Dai, Hui-Xiong.(2022).Functionalized styrene synthesis via palladium-catalyzed C-C cleavage of aryl ketones.TETRAHEDRON LETTERS,95,4. |
| MLA | Zhang, Xu,et al."Functionalized styrene synthesis via palladium-catalyzed C-C cleavage of aryl ketones".TETRAHEDRON LETTERS 95(2022):4. |
入库方式： OAI收割
来源：上海药物研究所
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