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Identification of HGD and GSTZ1 as Biomarkers Involved Metabolic Reprogramming in Kidney Renal Clear Cell Carcinoma

文献类型：期刊论文

作者Wang, Jiyan4,5; Chang, Hongkai4,5; Su, Meng3; Qiao, Yaya4,5; Sun, Huanran4,5; Zhao, Yongshan3; Zhang, Shuai2; Shan, Changliang1,4,5
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
出版日期2022-05-01
卷号23期号:9页码:14
关键词tyrosine metabolism fumarate metabolism reprogramming renal cell carcinoma
DOI10.3390/ijms23094583
通讯作者Zhang, Shuai(shuaizhang@tjutcm.edu.cn) ; Shan, Changliang(changliangshan@nankai.edu.cn)
英文摘要Kidney renal clear cell carcinoma (KIRC) with poor prognosis is the main histological subtype of renal cell carcinoma, accounting for more than 80% of patients. Most patients are diagnosed at an advanced stage due to being asymptomatic early on. Advanced KIRC has an extremely poor prognosis due to its inherent resistance to radiotherapy and chemotherapy. Therefore, a comprehensive understanding of the molecular mechanisms of KIRC and the development of effective early diagnostic and therapeutic strategies is urgently needed. In this study, we aimed to identify the prognosis-related biomarker and analyzed its relationship with tumor progression. Metabolic changes are an important feature of kidney cancer, where the reduction of fumarate allows us to target the tyrosine metabolic pathway. The homogentisate 1,2-dioxygenase (HGD) and glutathione S-transferase zeta 1 (GSTZ1) related with prognosis of KIRC was identified through bioinformatics analysis based on The Cancer Genome Atlas (TCGA) databases. Mechanistically, we found that decreased HGD and GSTZ1 promote aerobic glycolysis in KIRC, coordinate the balance of amino acid metabolism and energy metabolism in tumor cells, and ultimately activate the tumor cell cycle and tumor progression. In summary, we identified the tyrosine metabolizing enzymes HGD and GSTZ1 as biomarkers of KIRC, which will further the understanding of the tumor metabolism profile, provide novel strategies and theoretical support for diagnosing and treating KIRC and as referential for future clinical research.
WOS关键词GENE-EXPRESSION ; CANCER ; MANAGEMENT ; MUTATIONS ; TUMORS
资助项目National Nature Science Foundation of China[81973356] ; National Nature Science Foundation of China[81902826] ; National Nature Science Foundation of China[81672781] ; Natural Science Foundation of Tianjin[21JCZDJC00060] ; Natural Science Foundation of Tianjin[19JCYBJC29600] ; Natural Science Foundation of Tianjin[21JCYBJC00180] ; Fundamental Research Funds for the Central Universities of Nankai University[3206054] ; Fundamental Research Funds for the Central Universities of Nankai University[91923101] ; Fundamental Research Funds for the Central Universities of Nankai University[63213082] ; Fundamental Research Funds for the Central Universities of Nankai University[92122017] ; State Key Laboratory of Drug Research[SIMM2105KF-08] ; Innovative S&T Projects for Young Researchers of Tianjin Academy of Agricultural Science[201918]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000796119800001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/301095]  
专题新药研究国家重点实验室
通讯作者Zhang, Shuai; Shan, Changliang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 301617, Peoples R China
3.Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China
4.Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300350, Peoples R China
5.Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Jiyan,Chang, Hongkai,Su, Meng,et al. Identification of HGD and GSTZ1 as Biomarkers Involved Metabolic Reprogramming in Kidney Renal Clear Cell Carcinoma[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(9):14.
APA Wang, Jiyan.,Chang, Hongkai.,Su, Meng.,Qiao, Yaya.,Sun, Huanran.,...&Shan, Changliang.(2022).Identification of HGD and GSTZ1 as Biomarkers Involved Metabolic Reprogramming in Kidney Renal Clear Cell Carcinoma.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(9),14.
MLA Wang, Jiyan,et al."Identification of HGD and GSTZ1 as Biomarkers Involved Metabolic Reprogramming in Kidney Renal Clear Cell Carcinoma".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.9(2022):14.

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来源：上海药物研究所

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