Serum proteomic analysis reveals the cardioprotective effects of Shexiang Baoxin Pill and Suxiao Jiuxin Pill in a rat model of acute myocardial infarction & nbsp;
文献类型：期刊论文
| 作者 | Song, Nixue5,6; Lu, Dayun5,6; Wu, Gaosong4; Wang, Shisheng3; Zeng, Yuanyuan1; Zhao, Jing1; Meng, Qian6; He, Han6; Chen, Linlin4; Zhu, Hongwen6 |
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
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| 出版日期 | 2022-07-15 |
| 卷号 | 293页码:10 |
| 关键词 | Shexiang baoxin pill Suxiao jiuxin pill Cardiovascular disease Data independent acquisition Focal adhesion Platelet activation |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2022.115279 |
| 通讯作者 | Shen, Xiaoxu(jhxiaoxushen@163.com) ; Zhang, Weidong(wdzhangy@hotmail.com) ; Zhou, Hu(zhouhu@simm.ac.cn) |
| 英文摘要 | Ethnopharmacological relevance: Shexiang Baoxin Pill (SBP) and Suxiao Jiuxin Pill (SJP) are traditional Chinese medicines used to treat cardiovascular disease (CVD) in China. However, the mechanism of their therapeutic effect on CVD has not been clearly elucidated yet.& nbsp;Aims: The aim of this study is to investigate the cardioprotective effect of SBP and SJP in the treatment of acute myocardial infarction (AMI) model rats by applying serum proteomic approach.& nbsp;Materials and methods: The rat model of AMI was generated by ligating the left anterior descending coronary artery. 42 rats were randomly divided into four groups: sham-operating (Sham, n = 10) group, model (Mod, n = 8) group, Shexiang Baoxin pills pretreatment (SBP, n = 12) group and Suxiao Jiuxin pills pretreatment (SJP, n = 12) group. Data Independent Acquisition (DIA) proteomic approach was utilized to investigate the serum proteome from the rat individuals. The differentially expressed proteins were subsequently obtained with bioinformatic analysis.& nbsp;Results: DIA-MS identified 415 proteins within 42 samples, and 84 differentially expressed proteins may contribute to the therapeutic effects of SBP and SJP. GOBP and KEGG pathway analysis of 84 differentially expressed proteins revealed that the proteins were mainly involved in platelet activation and adhesion processes. All 84 differentially expressed proteins presented the same changing tendency in the SBP and SJP groups when compared with the Mod group. Among these 84 proteins, 25 proteins were found to be related to CVD. Among these 25 proteins, ACTB, ACTG1, FGA, FGB, FGG, PF4 and VWF were found to be involved in platelet aggregation and activation. FN1, HSPA5 and YWHAZ were associated with adhesion.& nbsp;Conclusions: The results of our study suggest that the cardioprotective effects of SBP and SJP are achieved through the modulation of focal adhesion, platelet activation pathways. |
| WOS关键词 | CORONARY-HEART-DISEASE ; BINDING SITE ; EXPRESSION ; PLASMA ; CARDIOMYOCYTES ; ANGIOGENESIS ; INFARCTION |
| 资助项目 | National Key Research and Development Program of China, China[2017YFC1700200] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000794983900004 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301110]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Shen, Xiaoxu; Zhang, Weidong; Zhou, Hu |
| 作者单位 | 1.Beijing Univ Chinese Med, Dongzhimen Hosp, 5 Haiyuncang, Beijing 100700, Peoples R China 2.Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China 3.Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network,MOH, Inst Syst Genet,Key Lab Transplant Engn & Immunol, Chengdu 610041, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, 1200 Cailun Rd, Shanghai 201203, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Song, Nixue,Lu, Dayun,Wu, Gaosong,et al. Serum proteomic analysis reveals the cardioprotective effects of Shexiang Baoxin Pill and Suxiao Jiuxin Pill in a rat model of acute myocardial infarction & nbsp; [J]. JOURNAL OF ETHNOPHARMACOLOGY,2022,293:10. |
| APA |
Song, Nixue.,Lu, Dayun.,Wu, Gaosong.,Wang, Shisheng.,Zeng, Yuanyuan.,...&Zhou, Hu.(2022). Serum proteomic analysis reveals the cardioprotective effects of Shexiang Baoxin Pill and Suxiao Jiuxin Pill in a rat model of acute myocardial infarction & nbsp; .JOURNAL OF ETHNOPHARMACOLOGY,293,10. |
| MLA |
Song, Nixue,et al." Serum proteomic analysis reveals the cardioprotective effects of Shexiang Baoxin Pill and Suxiao Jiuxin Pill in a rat model of acute myocardial infarction & nbsp; ".JOURNAL OF ETHNOPHARMACOLOGY 293(2022):10. |
入库方式： OAI收割
来源：上海药物研究所
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