Five glycosylated phenolic derivatives from the bark of Ilex rotunda Thunb. and their anti-inflammatory activities
文献类型：期刊论文
| 作者 | Peng, Shou2,3; Chen, Tong3; Wang, Ge2,3; Li, Chen-yue2,3; Liu, Wen-jing1; Wang, Wen-qiong3; Xuan, Li-jiang2,3
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| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2022-05-17 |
| 页码 | 8 |
| 关键词 | Ilex rotunda hemiterpene glycosides phenolic glycosides anti-inflammatory activity |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2022.2078323 |
| 通讯作者 | Wang, Wen-qiong(wenqiong1019@simm.ac.cn) ; Xuan, Li-jiang(ljxuan@simm.ac.cn) |
| 英文摘要 | Five new glycosylated phenolic derivatives, rotundosides A-E (1-5), and three known glycosides (6-8) were isolated from the 95% alcohol extract of the bark of Ilex rotunda. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature data. All new compounds possessed a [5-O-(E)-caffeoyl]-beta-D-apiofuranosyl-(1 -> 6)-beta-D-glucopyranosyl group. The anti-inflammatory properties of all isolated compounds were evaluated using a modified nitric oxide (NO) production in lipopolysaccharide (LPS)-induced leukemia cells in mouse macrophage (RAW264.7) method. Compound 8, dracunculifoside H, showed significant anti-inflammatory activity in vitro. |
| WOS关键词 | INFLAMMATORY MEDIATORS ; KERATINOCYTES ; CONSTITUENTS ; GLYCOSIDES ; AKT |
| 资助项目 | State Key Laboratory of Drug Research[SIMM 1601ZZ03] ; Youth Innovation Promotion Association ; Shanghai MunicipalScience and Technology Major Project |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000800524500001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301154]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Wen-qiong; Xuan, Li-jiang |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Medica, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Shou,Chen, Tong,Wang, Ge,et al. Five glycosylated phenolic derivatives from the bark of Ilex rotunda Thunb. and their anti-inflammatory activities[J]. NATURAL PRODUCT RESEARCH,2022:8. |
| APA | Peng, Shou.,Chen, Tong.,Wang, Ge.,Li, Chen-yue.,Liu, Wen-jing.,...&Xuan, Li-jiang.(2022).Five glycosylated phenolic derivatives from the bark of Ilex rotunda Thunb. and their anti-inflammatory activities.NATURAL PRODUCT RESEARCH,8. |
| MLA | Peng, Shou,et al."Five glycosylated phenolic derivatives from the bark of Ilex rotunda Thunb. and their anti-inflammatory activities".NATURAL PRODUCT RESEARCH (2022):8. |
入库方式： OAI收割
来源：上海药物研究所
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