Synthesis and Biochemical Evaluation of 8H-Indeno[1,2-d]thiazole Derivatives as Novel SARS-CoV-2 3CL Protease Inhibitors
文献类型：期刊论文
| 作者 | Wu, Jing5; Feng, Bo3,4; Gao, Li-Xin3,5; Zhang, Chun5; Li, Jia2,3,4 ; Xiang, Da-Jun1; Zang, Yi3; Wang, Wen-Long5
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| 刊名 | MOLECULES
 |
| 出版日期 | 2022-05-01 |
| 卷号 | 27期号:10页码:11 |
| 关键词 | COVID-19 M-pro inhibitors drug design and synthesis structure-activity relationships (SAR) |
| DOI | 10.3390/molecules27103359 |
| 通讯作者 | Xiang, Da-Jun(xiangdjxshospital@yeah.net) ; Zang, Yi(yzang@simm.ac.cn) ; Wang, Wen-Long(wenlongwang@jiangnan.edu.cn) |
| 英文摘要 | The COVID-19 pandemic caused by SARS-CoV-2 is a global burden on human health and economy. The 3-Chymotrypsin-like cysteine protease (3CL(pro)) becomes an attractive target for SARS-CoV-2 due to its important role in viral replication. We synthesized a series of 8H-indeno[1,2-d]thiazole derivatives and evaluated their biochemical activities against SARS-CoV-2 3CL(pro). Among them, the representative compound 7a displayed inhibitory activity with an IC50 of 1.28 +/- 0.17 mu M against SARS-CoV-2 3CL(pro). Molecular docking of 7a against 3CL(pro) was performed and the binding mode was rationalized. These preliminary results provide a unique prototype for the development of novel inhibitors against SARS-CoV-2 3CL(pro). |
| WOS关键词 | AGONIST ALLOSTERIC ENHANCERS ; 2-AMINOTHIAZOLES ; SAFETY |
| 资助项目 | science and technology development foundation of Wuxi[N2020X016] ; Natural Science Foundation of Jiangsu Province[BK20190608] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000804269700001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301157]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xiang, Da-Jun; Zang, Yi; Wang, Wen-Long |
| 作者单位 | 1.Xishan Peoples Hosp Wuxi City, Wuxi 214105, Jiangsu, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China 5.Jiangnan Univ, Sch Life Sci & Hlth Engn, Wuxi 214122, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Jing,Feng, Bo,Gao, Li-Xin,et al. Synthesis and Biochemical Evaluation of 8H-Indeno[1,2-d]thiazole Derivatives as Novel SARS-CoV-2 3CL Protease Inhibitors[J]. MOLECULES,2022,27(10):11. |
| APA | Wu, Jing.,Feng, Bo.,Gao, Li-Xin.,Zhang, Chun.,Li, Jia.,...&Wang, Wen-Long.(2022).Synthesis and Biochemical Evaluation of 8H-Indeno[1,2-d]thiazole Derivatives as Novel SARS-CoV-2 3CL Protease Inhibitors.MOLECULES,27(10),11. |
| MLA | Wu, Jing,et al."Synthesis and Biochemical Evaluation of 8H-Indeno[1,2-d]thiazole Derivatives as Novel SARS-CoV-2 3CL Protease Inhibitors".MOLECULES 27.10(2022):11. |
入库方式： OAI收割
来源：上海药物研究所
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