Advances of microRNAs in regulating mitochondrial function: new potential application in NAFLD treatment
文献类型：期刊论文
| 作者 | Yu, Chuwei1,2; Chen, Jing1,2 ; Ren, Jin1,2
|
| 刊名 | MOLECULAR BIOLOGY REPORTS
 |
| 出版日期 | 2022-05-25 |
| 页码 | 13 |
| ISSN号 | 0301-4851 |
| 关键词 | NAFLD Mitochondrion MiRNA Mitochondrial dysfunction Metabolic diseases |
| DOI | 10.1007/s11033-022-07503-0 |
| 通讯作者 | Chen, Jing(jingchen@simm.ac.cn) ; Ren, Jin(jren@cdser.simm.ac.cn) |
| 英文摘要 | Nonalcoholic fatty liver disease (NAFLD) is one of the most common metabolic diseases and closely associated with lipid disorder. Mitochondrion has been recognized to play a key role in lipid metabolism as the main site of energy metabolism in cells, and its dysfunction is involved in the progression of NAFLD. MicroRNAs (miRNAs), one of regulators in the pathogenesis of NAFLD, are discovered to modulate mitochondrial function by targeting mitochondrial proteins or mitochondrial-related factors, thereby improving or deteriorating NAFLD-associated pathologies. This review summarizes the differentially expressed miRNAs from clinical and experimental models of NAFLD with abilities in regulating mitochondrial function, expounds their underlying molecular mechanism and discusses their prospect and future research direction. |
| WOS关键词 | NONALCOHOLIC FATTY LIVER ; ECTOPIC DEPOSITION ; DISEASE ; EXPRESSION ; MIR-34A ; STEATOHEPATITIS ; DYSFUNCTION ; METABOLISM ; RESISTIN ; ACID |
| 资助项目 | Foundation of Shanghai Science and Technology Committee[21DZ2291100] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000802075300004 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301166]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Chen, Jing; Ren, Jin |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Safety Evaluat & Res, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Chuwei,Chen, Jing,Ren, Jin. Advances of microRNAs in regulating mitochondrial function: new potential application in NAFLD treatment[J]. MOLECULAR BIOLOGY REPORTS,2022:13. |
| APA | Yu, Chuwei,Chen, Jing,&Ren, Jin.(2022).Advances of microRNAs in regulating mitochondrial function: new potential application in NAFLD treatment.MOLECULAR BIOLOGY REPORTS,13. |
| MLA | Yu, Chuwei,et al."Advances of microRNAs in regulating mitochondrial function: new potential application in NAFLD treatment".MOLECULAR BIOLOGY REPORTS (2022):13. |
入库方式： OAI收割
来源：上海药物研究所
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