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Withaphysalins from Medicinal and Edible Physalis minima and Their Anti-inflammatory Activities

文献类型：期刊论文

作者Hu, Bintao4,5,6; Li, Han2,3; Tang, Chunping3,5; Ke, Chang-Qiang5,6; Geng, Meiyu2,3,4; Yao, Sheng4,5,6; Xie, Zuoquan2,4; Ye, Yang1,4,5,6
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2022-05-11
卷号70期号:18页码:5595-5609
关键词Physalis minima withaphysalin 14?-OH anti-inflammatory NF-?B
ISSN号0021-8561
DOI10.1021/acs.jafc.2c01519
通讯作者Yao, Sheng(yaosheng@simm.ac.cn) ; Xie, Zuoquan(zqxie@simm.ac.cn) ; Ye, Yang(yye@simm.ac.cn)
英文摘要Physalis minima is a medicinal and edible plant in China. In this study, 22 new withaphysalins, including a novel 1(10 -> 6)abeo-14 beta-hydroxy one (1) and other 15 unusual 14 beta-hydroxy ones (3-4, 6-17, 19), were isolated from the whole herbs of P. minima together with two known analogues (23-24). Their structures were established by extensive analysis of high-resolution electrospray ionization mass spectrometry, IR, and 1D and 2D NMR spectroscopic data. Their absolute configurations were determined by electronic circular dichroism (ECD) spectra and single-crystal X-ray crystallographic analyses, together with DFT NMR calculations. All isolated compounds were evaluated for their anti-inflammatory activity via measuring the colorimetric reporter of the secreted embryonic alkaline phosphatase gene driven by an IFN-beta minimal promoter fused to five copies of the NF-Kappa B consensus transcriptional response element and three copies of the c-Rel binding site in LPS-stimulated human THP1-Dual cells. Compounds 2, 5, 6, 9, 10, 11, and 20 showed significant anti-inflammatory effects with IC50 values in the range of 3.01-13.39 mu M. Among them, compounds 2 and 10 showed better anti-inflammatory effects to inhibit the secretion of IL-6, IL-1 beta, and TNF-alpha in LPS-stimulated THP1-Dual cells.
WOS关键词NF-KAPPA-B ; HEPATOCELLULAR-CARCINOMA ; WITHANOLIDES ; WITHAFERIN ; APOPTOSIS
资助项目National Key R&D Program of China[2017YFE0195100] ; National Natural Science Foundation of China[81903485] ; Science and Technology Commission of Shanghai Municipality[19431908100]
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
语种英语
WOS记录号WOS:000802050800011
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/301216]  
专题新药研究国家重点实验室
通讯作者Yao, Sheng; Xie, Zuoquan; Ye, Yang
作者单位1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Nat Prod Chem Dept, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
6.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Bintao,Li, Han,Tang, Chunping,et al. Withaphysalins from Medicinal and Edible Physalis minima and Their Anti-inflammatory Activities[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022,70(18):5595-5609.
APA Hu, Bintao.,Li, Han.,Tang, Chunping.,Ke, Chang-Qiang.,Geng, Meiyu.,...&Ye, Yang.(2022).Withaphysalins from Medicinal and Edible Physalis minima and Their Anti-inflammatory Activities.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,70(18),5595-5609.
MLA Hu, Bintao,et al."Withaphysalins from Medicinal and Edible Physalis minima and Their Anti-inflammatory Activities".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 70.18(2022):5595-5609.

入库方式： OAI收割

来源：上海药物研究所

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