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Intestinal Glucuronidation, Prior to Hepatic Glucuronidation, Plays an Important Role in the Low Circulating Levels of Calycosin

文献类型：期刊论文

作者Jiang, Haodong2,3; Liu, Huan2; Hu, Pei2; Chen, Shuoji2; Ye, Yaqing1,2; Huang, Chenggang2,3; Tian, Xiaoting2
刊名SEPARATIONS
出版日期2022-05-01
卷号9期号:5页码:15
关键词calycosin first-pass effect intestinal glucuronidation liver distribution metabolism
DOI10.3390/separations9050115
通讯作者Huang, Chenggang(cghuang@simm.ac.cn) ; Tian, Xiaoting(20190903@njucm.edu.cn)
英文摘要Calycosin is a dietary flavonoid with favorable activities, which seems to be inconsistent with its low circulating levels in vivo. To address this issue, we developed a strategy to understand calycosin distribution by integrating qualitative and quantitative analyses of calycosin and its metabolites in portal vein plasma, the liver, and systemic plasma after oral administration to rats. Consequently, 21 metabolites were characterized in total, including the first report of a reductive biotransformation and 14 new metabolites. Compared with the low levels of calycosin, calycosin glucuronides were predominant in circulation, and both the hepatic and intestinal regions contributed to the high exposure of these calycosin glucuronides. However, intestinal glucuronidation, prior to hepatic glucuronidation, plays a key role in the low circulating levels of calycosin.
WOS关键词TISSUE DISTRIBUTION ; IDENTIFICATION ; METABOLITES ; ABSORPTION ; ACTIVATION ; CALYCOSIN-7-O-BETA-D-GLUCOSIDE ; PHARMACOKINETICS ; DISPOSITION ; FLAVONOIDS ; ROOTS
资助项目National Natural Science Foundation of China[81973456] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2019280] ; Shanghai Municipal Science and Technology Major Project[TM202101H007] ; Open Project Program Foundation of Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education[GS20200601]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000801306500001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/301219]  
专题中国科学院上海药物研究所
通讯作者Huang, Chenggang; Tian, Xiaoting
作者单位1.Guangxi Univ Chinese Med, Guangxi Key Lab Translat Med Treating High Incide, Nanning 530200, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Haodong,Liu, Huan,Hu, Pei,et al. Intestinal Glucuronidation, Prior to Hepatic Glucuronidation, Plays an Important Role in the Low Circulating Levels of Calycosin[J]. SEPARATIONS,2022,9(5):15.
APA Jiang, Haodong.,Liu, Huan.,Hu, Pei.,Chen, Shuoji.,Ye, Yaqing.,...&Tian, Xiaoting.(2022).Intestinal Glucuronidation, Prior to Hepatic Glucuronidation, Plays an Important Role in the Low Circulating Levels of Calycosin.SEPARATIONS,9(5),15.
MLA Jiang, Haodong,et al."Intestinal Glucuronidation, Prior to Hepatic Glucuronidation, Plays an Important Role in the Low Circulating Levels of Calycosin".SEPARATIONS 9.5(2022):15.

入库方式： OAI收割

来源：上海药物研究所

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