Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring
文献类型：期刊论文
| 作者 | Xue, Lamei2; Sun, Juan2; Liu, Jinxin2; Hu, Chaoping1; Wu, Dandan12; Nie, Chenzhipeng2; Zhang, Kuiliang2; Wang, Yu2; Zhao, Lei1; Li, Xihua1 |
| 刊名 | EMBO REPORTS
 |
| 出版日期 | 2022-06-02 |
| 页码 | 17 |
| 关键词 | intergenerational effects metabolic homeostasis obesity secretin white adipose tissue browning |
| ISSN号 | 1469-221X |
| DOI | 10.15252/embr.202154132 |
| 通讯作者 | Wang, Li(wangli@jiangnan.edu.cn) ; Li, Yan(liyan0520@jiangnan.edu.cn) |
| 英文摘要 | Our knowledge of the coordination of intergenerational inheritance and offspring metabolic reprogramming by gastrointestinal endocrine factors is largely unknown. Here, we showed that secretin (SCT), a brain-gut peptide, is downregulated by overnutrition in pregnant mice and women. More importantly, genetic loss of SCT in the maternal gut results in undesirable phenotypes developed in offspring including enhanced high-fat diet (HFD)-induced obesity and attenuated browning of inguinal white adipose tissue (iWAT). Mechanistically, loss of maternal SCT represses iWAT browning in offspring by a global change in genome methylation pattern through upregulation of DNMT1. SCT functions to facilitate ubiquitination and degradation of DNMT1 by activating AMPK alpha, which contributes to the observed alteration of DNMT1 in progeny. Lastly, we showed that SCT treatment during pregnancy can reduce the development of obesity and improve glucose tolerance and insulin resistance in offspring of HFD-fed females, suggesting that SCT may serve as a novel biomarker or a strategy for preventing metabolic diseases. |
| WOS关键词 | SCALE DNA METHYLATION ; BEIGE ; ADIPOCYTES ; MECHANISMS ; THERMOGENESIS ; ACTIVATION ; EXPOSURE ; PLACENTA ; DISEASE ; CANCER |
| 资助项目 | MOST of China[2021YFA1100500] ; National NSFC[31900841] ; National NSFC[32071166] ; National NSFC[91957205] ; National NSFC[81801541] ; Fundamental Research Funds for the Central Universities[JUSRP221001] ; Young Elite Scientists Sponsorship Program by CAST[2020QNRC001] ; Pujiang Talent Program from STCSM[18PJ1401800] ; NHC Key Laboratory of Food Safety Risk Assessment[2020K02] ; Qinglan Project of Jiangsu Province of China ; HK Government GRF[HKU 17113120] ; HK Government GRF[HKU 17127718] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000804611700001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301292]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Li; Li, Yan |
| 作者单位 | 1.Fudan Univ, Dept Neuromuscular Dis, Childrens Hosp, Shanghai, Peoples R China 2.Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi, Jiangsu, Peoples R China 3.Univ Hong Kong, Sch Biol Sci, Hong Kong, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Chinese Acad Sci Key Lab Nutr Metab & Food Safety, Shanghai, Peoples R China 5.East China Normal Univ, Sch Life Sci, Shanghai, Peoples R China 6.East China Normal Univ, Shanghai Key Lab Regulatory Biol, Inst Biomed Sci, Fengxian Dist Cent Hosp ECNU Joint Ctr Translat M, Shanghai, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 8.Charlie Norwood VA Med Ctr, Augusta, GA USA 9.Univ Georgia, Coll Pharm, Clin & Expt Therapeut, Augusta, GA USA 10.Jinan Univ, Guangdong Hong Kong Macau Inst CNS Regenerat, Joint Int Res Lab CNS Regenerat, Guangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Lamei,Sun, Juan,Liu, Jinxin,et al. Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring[J]. EMBO REPORTS,2022:17. |
| APA | Xue, Lamei.,Sun, Juan.,Liu, Jinxin.,Hu, Chaoping.,Wu, Dandan.,...&Li, Yan.(2022).Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring.EMBO REPORTS,17. |
| MLA | Xue, Lamei,et al."Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring".EMBO REPORTS (2022):17. |
入库方式： OAI收割
来源：上海药物研究所
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