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Anti-inflammatory sesquiterpenoid dimers from Artemisia atrovirens

文献类型：期刊论文

作者Shao, Zhengguang3,4; Li, Lizhi2,4; Zheng, Yongzhe3,4; Gong, Qi1; Ke, Chang-Qiang4; Yao, Sheng4; Zhang, Haiyan1,3; Tang, Chunping4; Ye, Yang2,3,4
刊名FITOTERAPIA
出版日期2022-06-01
卷号159页码:10
ISSN号0367-326X
关键词Artemisia atrovirens Sesquiterpenoid dimer Guaianolide TDDFT ECD calculation Artatrovirenolides A-H
DOI10.1016/j.fitote.2022.105199
通讯作者Tang, Chunping() ; Ye, Yang(yye@simm.ac.cn)
英文摘要Eight new sesquiterpenoid dimers, artatrovirenolides A-H (1-8), along with three known analogues (9-11), were isolated from Artemisia atrovirens by using the LC-MS guided isolation. Compound 1 was a compound dimerized from a guaianolide and a 1,10-seco-guaianolide unit while others were from two guaianolide units. Their structures were established by comprehensive analysis of spectroscopic data, and their absolute configurations were determined by the aid of time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculation. Compound 8 showed anti-inflammatory effect in LPS-stimulated BV-2 microglial cells at 1 mu M, while compounds 1, 2, 5, and 6 inhibited microglial inflammation at 10 mu M.
WOS关键词GUAIANOLIDES ; LACTONES
资助项目National Key R&D Program of China[2017YFE0195100] ; Key-Area Research and Development Program of Guangdong Province[2020B0303070002]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者ELSEVIER
WOS记录号WOS:000799025800008
源URL[http://119.78.100.183/handle/2S10ELR8/301295]  
专题新药研究国家重点实验室
通讯作者Tang, Chunping; Ye, Yang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Shao, Zhengguang,Li, Lizhi,Zheng, Yongzhe,et al. Anti-inflammatory sesquiterpenoid dimers from Artemisia atrovirens[J]. FITOTERAPIA,2022,159:10.
APA Shao, Zhengguang.,Li, Lizhi.,Zheng, Yongzhe.,Gong, Qi.,Ke, Chang-Qiang.,...&Ye, Yang.(2022).Anti-inflammatory sesquiterpenoid dimers from Artemisia atrovirens.FITOTERAPIA,159,10.
MLA Shao, Zhengguang,et al."Anti-inflammatory sesquiterpenoid dimers from Artemisia atrovirens".FITOTERAPIA 159(2022):10.

入库方式： OAI收割

来源：上海药物研究所

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