Near-Infrared Window II Fluorescence Image-Guided Surgery of High-Grade Gliomas Prolongs the Progression-Free Survival of Patients
文献类型：期刊论文
| 作者 | Shi, Xiaojing6,7; Zhang, Zhe5; Zhang, Zeyu4,7; Cao, Caiguang6,7; Cheng, Zhen3; Hu, Zhenhua6,7; Tian, Jie2,4,6,7; Ji, Nan1,2,5 |
| 刊名 | IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
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| 出版日期 | 2022-06-01 |
| 卷号 | 69期号:6页码:1889-1900 |
| 关键词 | Imaging Fluorescence Tumors Biomedical imaging Molecular imaging Neurosurgery Image color analysis Near-infrared window II fluorescence image-guided surgery glioblastoma indocyanine green |
| ISSN号 | 0018-9294 |
| DOI | 10.1109/TBME.2021.3130195 |
| 通讯作者 | Cheng, Zhen(zcheng@simm.ac.cn) ; Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Ji, Nan(jinan@bjtth.org) |
| 英文摘要 | Objective: This translational study aims to investigate the clinical benefits of indocyanine green (ICG) based near-infrared window II (NIR-II) fluorescence image-guided surgery (FGS) on high-grade glioma (HGG) patients. Methods: Patients were randomly assigned to receive FGS or traditional white light image-guided surgery (WLS). The detection rate of NIR-II fluorescence was observed. Complete resection rate, progression-free survival (PFS), overall survival (OS), and neurological status were compared. Tissue samples were obtained from the FGS group, with the diagnosis based on the surgeons and the fluorescence recorded for comparison of diagnostic capability. Patients with WHO grade III gliomas or glioblastomas (GBM) were analyzed separately. Results: 15 GBM and 4 WHO grade III glioma patients in the FGS group and 18 GBM and 4 WHO grade III glioma patients in the WLS group were enrolled. The detection rate of NIR-II fluorescence was 100% for GBM. The complete resection rate was significantly increased by the FGS for GBM (FGS, 100% [95% CI 73.41-100] vs. WLS, 50% [95% CI 29.03-70.97], P = 0.0036). The PFS and OS of the FGS group were also significantly prolonged (Median PFS: FGS, 9.0 months vs. WLS, 7.0 months, P < 0.0001; Median OS: FGS, 19.0 months vs. WLS, 15.5 months, P = 0.0002). No recurrence was observed in WHO grade III glioma patients. Conclusions: NIR-II FGS achieves a much better complete resection rate of GBM than conventional WLS, leading to greatly improved survival of GBM patients. Significance: NIR-II FGS is a highly promising technique worthy of exploring more clinical applications. |
| WOS关键词 | RESECTION ; GLIOBLASTOMA ; BRAIN ; 1ST-IN-HUMAN |
| 资助项目 | National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2017YFC1309100] ; National Natural Science Foundation of China (NSFC)[62027901] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[92059207] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[81930048] ; Beijing Natural Science Foundation[JQ19027] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16021200] ; innovative research team of high-level local universities in Shanghai ; Zhuhai High-level Health Personnel Team Project[HLHPTP201703] ; Capital characteristic clinical application project[Z181100001718196] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:000799622400012 |
| 出版者 | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301307]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Cheng, Zhen; Hu, Zhenhua; Tian, Jie; Ji, Nan |
| 作者单位 | 1.China Natl Clin Res Ctr Neurol Dis, Beijing 100070, Peoples R China 2.Beihang Univ, Sch Med, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100191, Peoples R China 3.Chinese Acad Sci, Mol Imaging Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Peoples R China 5.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100070, Peoples R China 6.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 7.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Beijing Key Lab Mol Imaging, CAS Key Lab Mol Imaging,Inst Automat, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Xiaojing,Zhang, Zhe,Zhang, Zeyu,et al. Near-Infrared Window II Fluorescence Image-Guided Surgery of High-Grade Gliomas Prolongs the Progression-Free Survival of Patients[J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,2022,69(6):1889-1900. |
| APA | Shi, Xiaojing.,Zhang, Zhe.,Zhang, Zeyu.,Cao, Caiguang.,Cheng, Zhen.,...&Ji, Nan.(2022).Near-Infrared Window II Fluorescence Image-Guided Surgery of High-Grade Gliomas Prolongs the Progression-Free Survival of Patients.IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,69(6),1889-1900. |
| MLA | Shi, Xiaojing,et al."Near-Infrared Window II Fluorescence Image-Guided Surgery of High-Grade Gliomas Prolongs the Progression-Free Survival of Patients".IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 69.6(2022):1889-1900. |
入库方式： OAI收割
来源：上海药物研究所
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