Liver injury long-term monitoring and fluorescent image-guided tumor surgery using self-assembly amphiphilic donor-acceptor NIR-II dyes
文献类型：期刊论文
| 作者 | Qiu, Qing2,4; Chang, Tonghang2,3; Wu, Yuyang; Qu, Chunrong2; Chen, Hao2,3; Cheng, Zhen1,2,3 |
| 刊名 | BIOSENSORS & BIOELECTRONICS
 |
| 出版日期 | 2022-09-15 |
| 卷号 | 212页码:10 |
| 关键词 | NIR-II imaging Amphiphilic dye Self-assembled Liver function monitoring Image-guided surgery |
| ISSN号 | 0956-5663 |
| DOI | 10.1016/j.bios.2022.114371 |
| 通讯作者 | Qu, Chunrong() ; Chen, Hao(haoc@simm.ac.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | Real-time monitoring of liver dysfunction represents a significant unmet demand in clinical and preclinical research. The second near-infrared window (NIR-II, 1000-1700 nm) fluorescent imaging is an attractive method for biomedical imaging and may be a promising approach for liver dysfunction monitoring. Herein, we designed and synthesized a small-molecule NIR-II dye TQT 1009 with an asymmetric donor-acceptor (D-A) core. By introducing four kinds of polyethylene glycol (PEG) with different length and molecular weights (nK, n = 0.5, 2, 5, 10) to TQT1009, the dye was self-assembled into different nanoparticles named as TQP nK with regulated size and controllable circulation lifetime in vivo. In general, TQP nK showed a super high contrast ratio for blood vessels, bones, intestines, lymph, and tumor imaging. The best-selected probe, TQP 10K, exhibited ultralong in vivo circulation time (>96 h) which was suitable for long-term quantitative monitoring of liver and vessel function at a single dose, implying the excellent prospects compared with ICG, which was quickly eliminated in blood within a few minutes. Meanwhile, TQP 10K also achieved NIR-II surgical navigation of tumor in an extended time window (>7 d). Overall, our results demonstrate the self-assembly PEGylated amphiphilic TQP nK provide a new probe design strategy for liver function monitoring and image-guided tumor surgery in a prolonged time window. |
| WOS关键词 | NEAR-INFRARED WINDOW ; FLUOROPHORES ; NANOPARTICLES ; TIME |
| 资助项目 | National Science and Technology Innovation 2030 Major Project of China[2021ZD0203900] ; Shanghai Municipal Science and Technology Major Project ; Lingang Laboratory[2021ZD0203900] ; National Natural Science Foundation of China[81901799] ; National Natural Science Foundation of China[82071976] ; Shanghai Pujiang Program[19PJ1411100] ; [LG-QS-202206-01] |
| WOS研究方向 | Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000806387900001 |
| 出版者 | ELSEVIER ADVANCED TECHNOLOGY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301343]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Qu, Chunrong; Chen, Hao; Cheng, Zhen |
| 作者单位 | 1.Bohai rim Adv Res Inst Drug Discovery, Yantai 264000, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Nanchang Univ, Sch Pharm, 461 Bayi Rd, Nanchang 330006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, Qing,Chang, Tonghang,Wu, Yuyang,et al. Liver injury long-term monitoring and fluorescent image-guided tumor surgery using self-assembly amphiphilic donor-acceptor NIR-II dyes[J]. BIOSENSORS & BIOELECTRONICS,2022,212:10. |
| APA | Qiu, Qing,Chang, Tonghang,Wu, Yuyang,Qu, Chunrong,Chen, Hao,&Cheng, Zhen.(2022).Liver injury long-term monitoring and fluorescent image-guided tumor surgery using self-assembly amphiphilic donor-acceptor NIR-II dyes.BIOSENSORS & BIOELECTRONICS,212,10. |
| MLA | Qiu, Qing,et al."Liver injury long-term monitoring and fluorescent image-guided tumor surgery using self-assembly amphiphilic donor-acceptor NIR-II dyes".BIOSENSORS & BIOELECTRONICS 212(2022):10. |
入库方式： OAI收割
来源：上海药物研究所
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