Palladium-Catalyzed Alkynylation of Enones with Alkynylsilanes via C-C Bond Activation
文献类型：期刊论文
| 作者 | Liu, Yu-Wen2,3; Li, Ling-Jun2,3; Xu, Hui3; Dai, Hui-Xiong1,2,3
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2022-05-20 |
| 卷号 | 87期号:10页码:6807-6811 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.2c00498 |
| 通讯作者 | Dai, Hui-Xiong(hxdai@simm.ac.cn) |
| 英文摘要 | We report herein the synthesis of 1,3-enynes via palladium-catalyzed cross-coupling between enone derivatives and alkynylsilanes. The employment of an appropriate pyridine-oxazoline ligand is the key to the C-C cleavage and the high E/Z stereoselectivity. This protocol features broad substrate scope and wide functional-group tolerance, affording the desired products in moderate-to-good yields. Late-stage diversification of natural product beta-ionone further demonstrated the synthetic utility of this protocol. |
| WOS关键词 | H ALKYNYLATION ; SONOGASHIRA REACTION ; ARYL KETONES ; OXIME ESTERS ; 1,3-ENYNES ; ALKENES ; LIGAND ; FUNCTIONALIZATION ; CYCLIZATIONS ; ACRYLAMIDES |
| 资助项目 | Shanghai Institute of Materia Medica ; Chinese Academy of Sciences ; National Natural Science Foundation of China[22171276] ; National Natural Science Foundation of China[21920102003] ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120163006] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Science and Technology Commission of Shanghai Municipality[21ZR1475400] ; Science and Technology Commission of Shanghai Municipality[18431907100] ; Program of Shanghai Academic Research Leader[19XD1424600] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000805365600022 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301346]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Dai, Hui-Xiong |
| 作者单位 | 1.Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yu-Wen,Li, Ling-Jun,Xu, Hui,et al. Palladium-Catalyzed Alkynylation of Enones with Alkynylsilanes via C-C Bond Activation[J]. JOURNAL OF ORGANIC CHEMISTRY,2022,87(10):6807-6811. |
| APA | Liu, Yu-Wen,Li, Ling-Jun,Xu, Hui,&Dai, Hui-Xiong.(2022).Palladium-Catalyzed Alkynylation of Enones with Alkynylsilanes via C-C Bond Activation.JOURNAL OF ORGANIC CHEMISTRY,87(10),6807-6811. |
| MLA | Liu, Yu-Wen,et al."Palladium-Catalyzed Alkynylation of Enones with Alkynylsilanes via C-C Bond Activation".JOURNAL OF ORGANIC CHEMISTRY 87.10(2022):6807-6811. |
入库方式： OAI收割
来源：上海药物研究所
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