Diterpenoids from Sauropus spatulifolius Leaves with Antimicrobial Activities
文献类型：期刊论文
| 作者 | Wu, Pei-Qian2,3; Cui, Yong-Sheng2,3; Han, Xiao-Ying1; Wang, Chen1; An, Pei-Pei2,3; Zhou, Jun-Su2; Ren, Yu-Hao2; Liu, Zhen-Long1; Lin, Rong-Tuan1; Zhou, Bin2 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2022-05-27 |
| 卷号 | 85期号:5页码:1304-1314 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.2c00020 |
| 通讯作者 | Zhou, Bin(zbbrush@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | As a plant used in both food and medicine, Sauropus spatulifolius is consumed widely as a natural herbal tea, food source, and Chinese medicine. Inspired by its extensive applications, we conducted a systematic phytochemical study of the leaves of S. spatulifolius. Thirteen new diterpenoids, sauspatulifols A-M (1-13), including four ent-cleistanthane-type diterpenoids (1-4), eight 15,16-di-nor-ent-cleistanthane-type diterpenoids (5-12), and one 17-nor-ent-pimarane-type diterpenoid (13) as well as one known diterpenoid, cleistanthol (14), were isolated. All of these diterpenoids feature a 2 alpha,3 alpha-dihydroxy unit within the A ring, and their structures were elucidated by spectroscopic data analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction analysis. Compound 14 displayed moderate inhibitory activity against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, and Shigella flexneri with the same minimum inhibitory concentration value of 12 mu g/mL as well as activity against vesicular stomatitis virus and influenza A virus. |
| 资助项目 | National Natural Science Foundation[22177122] ; National Natural Science Foundation[81861138045] ; Shanghai Municipal Science and Technology Major Project, the Biological Resources Program, CAS[KFJ-BRP-008-001] ; Shanghai Pujiang Program[21PJ1416000] ; Canadian Institutes of Health Research[PJT-148657] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000806554600013 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301358]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Bin; Yue, Jian-Min |
| 作者单位 | 1.McGill Univ, Lady Davis Inst Jewish Gen Hosp, Dept Med, Montreal, PQ H3T 1E2, Canada 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Pei-Qian,Cui, Yong-Sheng,Han, Xiao-Ying,et al. Diterpenoids from Sauropus spatulifolius Leaves with Antimicrobial Activities[J]. JOURNAL OF NATURAL PRODUCTS,2022,85(5):1304-1314. |
| APA | Wu, Pei-Qian.,Cui, Yong-Sheng.,Han, Xiao-Ying.,Wang, Chen.,An, Pei-Pei.,...&Yue, Jian-Min.(2022).Diterpenoids from Sauropus spatulifolius Leaves with Antimicrobial Activities.JOURNAL OF NATURAL PRODUCTS,85(5),1304-1314. |
| MLA | Wu, Pei-Qian,et al."Diterpenoids from Sauropus spatulifolius Leaves with Antimicrobial Activities".JOURNAL OF NATURAL PRODUCTS 85.5(2022):1304-1314. |
入库方式： OAI收割
来源：上海药物研究所
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