Calysepins I-VII, Hexasaccharide Resin Glycosides from Calystegia sepium and Their Cytotoxic Evaluation
文献类型：期刊论文
| 作者 | Lv, Kai-Qing4,5; Ji, Hong-Ying2,3; Du, Gao-Xiang4,5; Peng, Shou1,4; Guo, Peng-Ju1,4; Wang, Ge1,4; Zhu, Yao1,4; Wang, Qing1,4; Wang, Wen-Qiong4; Xuan, Li-Jiang4,5
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2022-05-27 |
| 卷号 | 85期号:5页码:1294-1303 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.2c00008 |
| 通讯作者 | Wang, Wen-Qiong(wenqiong1019@126.com) ; Xuan, Li-Jiang(ljxuan@simm.ac.cn) |
| 英文摘要 | Seven new hexasaccharide resin glycosides, named calysepins I-VII (1-7), with 27-membered rings, were obtained from the aerial parts of Calystegia sepium. Their structures with absolute configuration were established on the basis of spectroscopic data interpretation analysis and the use of chemical methods. They were defined as hexasaccharides composed of one d-quinovose, four d-glucose, and one l-rhamnose unit, and their sugar moieties were partially acylated by (2S)-methylbutanoic acid in 1-7 and (2R,3R)-nilic acid in 1-5 and 7, which mainly differed at the positions of acylation. Additionally, calysepin IV (4) exhibited cytotoxicity against A549 cells with an IC50 value of 5.2 mu M. |
| WOS关键词 | SEEDS |
| 资助项目 | State Key Laboratory of Drug Research[SIMM1601ZZ-03] ; Youth Innovation Promotion Association[2019284] ; Shanghai Municipal Science and Technology Major Project[TM202101H008] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000806554600012 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301401]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Wen-Qiong; Xuan, Li-Jiang |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Hebei Med Univ, Dept Pharmacol, Key Lab Neural & Vasc Biol, Key Lab New Drug Pharmacol & Toxicol,Minist Educ, Shijiazhuang 050017, Hebei, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Stake Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Kai-Qing,Ji, Hong-Ying,Du, Gao-Xiang,et al. Calysepins I-VII, Hexasaccharide Resin Glycosides from Calystegia sepium and Their Cytotoxic Evaluation[J]. JOURNAL OF NATURAL PRODUCTS,2022,85(5):1294-1303. |
| APA | Lv, Kai-Qing.,Ji, Hong-Ying.,Du, Gao-Xiang.,Peng, Shou.,Guo, Peng-Ju.,...&Xuan, Li-Jiang.(2022).Calysepins I-VII, Hexasaccharide Resin Glycosides from Calystegia sepium and Their Cytotoxic Evaluation.JOURNAL OF NATURAL PRODUCTS,85(5),1294-1303. |
| MLA | Lv, Kai-Qing,et al."Calysepins I-VII, Hexasaccharide Resin Glycosides from Calystegia sepium and Their Cytotoxic Evaluation".JOURNAL OF NATURAL PRODUCTS 85.5(2022):1294-1303. |
入库方式： OAI收割
来源：上海药物研究所
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