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Strategies of engineering nanomedicines for tumor retention

文献类型：期刊论文

作者Qian, Xindi3,5,6; Xu, Xiaoxuan3,5,6; Wu, Yao4,5,6; Wang, Jiaoying5,6; Li, Jie5,6; Chen, Shuo2; Wen, Jingyuan2; Li, Yaping1,3,4,5,6; Zhang, Zhiwen3,4,5,6
刊名JOURNAL OF CONTROLLED RELEASE
出版日期2022-06-01
卷号346页码:193-211
关键词Nanomedicines Tumor retention Drug delivery Size-enlargement Morphology changes
ISSN号0168-3659
DOI10.1016/j.jconrel.2022.04.006
通讯作者Li, Yaping(ypli@simm.ac.cn) ; Zhang, Zhiwen(zhangzhiwen@fudan.edu.cn)
英文摘要The retention of therapeutic agents in solid tumors at sufficient concentration and duration is crucial for their antitumor effects. Given the important contribution of nanomedicines to oncology, we herein summarized two major strategies of nanomedicines for tumor retention, such as transformation-and interactions-mediated strategies. The transformation-mediated retention strategy was achieved by enlarging particle size of nano medicines or modulating the morphology into fibrous structures, while the interactions-mediated retention strategy was accomplished by modulating nanomedicines to promote their interactions with versatile cells or components in tumors. Moreover, we provide some considerations and perspectives of tumor-retaining nano medicines for effective cancer therapy.
WOS关键词TARGETED DRUG-DELIVERY ; EXTRACELLULAR-MATRIX ; ENHANCED PERMEABILITY ; WORMLIKE MICELLES ; GOLD NANOPARTICLE ; LUNG METASTASIS ; CELLULAR UPTAKE ; SURFACE-CHARGE ; BLOOD-VESSELS ; CANCER
资助项目National Natural Science Foundation of China[32071385] ; National Natural Science Foundation of China[31930066] ; Shandong Provincial Natural Science Foundation of China[ZR2019ZD25] ; Fudan-SIMM Joint Research Fund[FU-SIMM20182005]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000807912300001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/301407]  
专题新药研究国家重点实验室
通讯作者Li, Yaping; Zhang, Zhiwen
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
2.Univ Auckland, Sch Pharm, Auckland 1142, New Zealand
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
6.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Qian, Xindi,Xu, Xiaoxuan,Wu, Yao,et al. Strategies of engineering nanomedicines for tumor retention[J]. JOURNAL OF CONTROLLED RELEASE,2022,346:193-211.
APA Qian, Xindi.,Xu, Xiaoxuan.,Wu, Yao.,Wang, Jiaoying.,Li, Jie.,...&Zhang, Zhiwen.(2022).Strategies of engineering nanomedicines for tumor retention.JOURNAL OF CONTROLLED RELEASE,346,193-211.
MLA Qian, Xindi,et al."Strategies of engineering nanomedicines for tumor retention".JOURNAL OF CONTROLLED RELEASE 346(2022):193-211.

入库方式： OAI收割

来源：上海药物研究所

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