Metabolic Regulation of CD8(+) T Cells: From Mechanism to Therapy
文献类型：期刊论文
| 作者 | Zheng, Ying2,3; Wang, Xiaomin1,2,3; Huang, Min1,2,3
|
| 刊名 | ANTIOXIDANTS & REDOX SIGNALING
 |
| 出版日期 | 2022-06-02 |
| 页码 | 20 |
| 关键词 | cancer immunotherapy CD8(+) T cells metabolic reprogramming tumor microenvironment |
| ISSN号 | 1523-0864 |
| DOI | 10.1089/ars.2022.0040 |
| 通讯作者 | Wang, Xiaomin(wangxiaomin3@simm.ac.cn) ; Huang, Min(mhuang@simm.ac.cn) |
| 英文摘要 | Significance: Cancer immunotherapy has yielded striking antitumor effects in many cancers, yet the proportion of benefited patients is still limited. As key mediators of tumor suppression, CD8(+) T cells are crucial for cancer immunotherapy. It has been widely appreciated that the modulation of CD8(+) T cell immunity could be an effective way to further improve the therapeutic benefit of immunotherapy.Recent Advances: Emerging evidence has underlined a close link between metabolism and immune functions, providing a metabolism-immune axis that is increasingly investigated for understanding CD8(+) T cell regulation. On the other hand, growing findings have reported that tumors adopt multiple approaches to induce metabolic reprogramming of CD8(+) T cells, leading to compromised immunotherapy.Critical Issues: CD8(+) T cell metabolism in the tumor microenvironment (TME) is often adapted to diminish antitumor immune responses and thereby evade from immune surveillance. A better understanding of metabolic regulation of CD8(+) T cells in the TME is believed to hold promise for opening a new therapeutic window to further improve the benefit of immunotherapy. We herein review the mechanistic understanding of how CD8(+) T cell metabolism is reprogrammed in the TME, mainly focusing on the impact of nutrient availability and bioactive molecules secreted by surrounding cells.Future Directions: Future research should pay attention to tumor heterogeneity in the metabolic microenvironment and associated immune responses. It is also important to include the trending opinion of "precision medicine" in cancer immunotherapies to tailor metabolic interventions for individual patients in combination with immunotherapy treatments. |
| WOS关键词 | A2A ADENOSINE RECEPTOR ; INDOLEAMINE 2,3-DIOXYGENASE ; ACQUIRED-RESISTANCE ; EFFECTOR FUNCTION ; LACTIC-ACID ; HYPOXIA ; EXPRESSION ; SURVIVAL ; MEMORY ; ACTIVATION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000805675200001 |
| 出版者 | MARY ANN LIEBERT, INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301416]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Xiaomin; Huang, Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Ying,Wang, Xiaomin,Huang, Min. Metabolic Regulation of CD8(+) T Cells: From Mechanism to Therapy[J]. ANTIOXIDANTS & REDOX SIGNALING,2022:20. |
| APA | Zheng, Ying,Wang, Xiaomin,&Huang, Min.(2022).Metabolic Regulation of CD8(+) T Cells: From Mechanism to Therapy.ANTIOXIDANTS & REDOX SIGNALING,20. |
| MLA | Zheng, Ying,et al."Metabolic Regulation of CD8(+) T Cells: From Mechanism to Therapy".ANTIOXIDANTS & REDOX SIGNALING (2022):20. |
入库方式： OAI收割
来源：上海药物研究所
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