Tumor-Targeted Theranostic Probe for Near Infrared II Window Fluorescence Imaging and Anticancer Therapy of Triple-Negative Breast Cancer
文献类型：期刊论文
| 作者 | Zou Zhi-Feng1,2,3; Gao Jing1,2; Lai Yi1,2; Xu Zhi-Ai3 |
| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2022-06-01 |
| 卷号 | 50期号:6页码:912-923 |
| 关键词 | Active targeting Near infrared II region fluorescence Photothermal therapy Theranostic Triple negative breast cancer |
| ISSN号 | 0253-3820 |
| DOI | 10.19756/j?ssn.0253-3820.221115 |
| 通讯作者 | Xu Zhi-Ai(zaxu@chem.ecnu.edu.cn) |
| 英文摘要 | Donor-acceptor-donor(D-A-D)type fluorescent probes have been widely used in biological imaging due to their excellent optical stability and biocompatibility. By molecular engineering, the fluorescence emission of D-A-D type probe can shift to the near infrared II window(NIR-II), which shows that the probe has potential for bioimaging and photothermal therapy due to its good photothermal conversion efficiency. However, its large molecular weight leads to unavoidable disadvantages such as poor water solubility, which seriously limits its application. Therefore, in this work, an actively targeted polymer(CRGDK-PEG-b-PLGA)was designed to improve the water-solubility, tumor-specificity and photothermal efficacy of D-A-D type fluorescent probe(TQTCD), thus achieving the integration of diagnosis and treatment. CRGDK-PEG-b-PLGA and TQTCD could self-assemble to form homogeneous and stable nanoparticles (named RPP@TQTCD). This strategy did not affect the fluorescence properties and photothermal effects of TQTCD. CRGDK ligand-modification could increase the tumor accumulation of RPP@TQTCD NPs and interact with the Neuropilin-1(NRP-1)receptor, which was highly expressed on the surface of tumor cells, to promote cellular uptake of RPP@TQTCD NPs through NRP-1-CRGDK pathway. Then, RPP@TQTCD NPs could effectively kill tumor cells under 808 nm laser irradiation in vitro and in vivo. This study provided an effective strategy for the diagnosis and photothermal treatment of triple negative breast cancer (TNBC)through the targeted delivery of hydrophobic probe. |
| WOS关键词 | CHEMOTHERAPY |
| 资助项目 | National Natural Science Foundation of China[22074043] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000809498000001 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301465]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu Zhi-Ai |
| 作者单位 | 1.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zou Zhi-Feng,Gao Jing,Lai Yi,et al. Tumor-Targeted Theranostic Probe for Near Infrared II Window Fluorescence Imaging and Anticancer Therapy of Triple-Negative Breast Cancer[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2022,50(6):912-923. |
| APA | Zou Zhi-Feng,Gao Jing,Lai Yi,&Xu Zhi-Ai.(2022).Tumor-Targeted Theranostic Probe for Near Infrared II Window Fluorescence Imaging and Anticancer Therapy of Triple-Negative Breast Cancer.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,50(6),912-923. |
| MLA | Zou Zhi-Feng,et al."Tumor-Targeted Theranostic Probe for Near Infrared II Window Fluorescence Imaging and Anticancer Therapy of Triple-Negative Breast Cancer".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 50.6(2022):912-923. |
入库方式： OAI收割
来源：上海药物研究所
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