Methionine cycle in nonalcoholic fatty liver disease and its potential applications
文献类型：期刊论文
| 作者 | Wang, Haoyu1,2; Wu, Yanwei1; Tang, Wei1,2
|
| 刊名 | BIOCHEMICAL PHARMACOLOGY
 |
| 出版日期 | 2022-06-01 |
| 卷号 | 200页码:17 |
| 关键词 | Methionine Cycle NAFLD |
| ISSN号 | 0006-2952 |
| DOI | 10.1016/j.bcp.2022.115033 |
| 通讯作者 | Wu, Yanwei(wuyanwei@simm.ac.cn) ; Tang, Wei(tangwei@simm.ac.cn) |
| 英文摘要 | As a chronic metabolic disease affecting epidemic proportions worldwide, the pathogenesis of Nonalcoholic Fatty Liver Disease (NAFLD) is not clear yet. There is also a lack of precise biomarkers and specific medicine for the diagnosis and treatment of NAFLD. Methionine metabolic cycle, which is critical for the maintaining of cellular methylation and redox state, is involved in the pathophysiology of NAFLD. However, the molecular basis and mechanism of methionine metabolism in NAFLD are not completely understood. Here, we mainly focus on specific enzymes that participates in methionine cycle, to reveal their interconnections with NAFLD, in order to recognize the pathogenesis of NAFLD from a new angle and at the same time, explore the clinical characteristics and therapeutic strategies. |
| WOS关键词 | CYSTATHIONINE BETA-SYNTHASE ; HOMOCYSTEINE S-METHYLTRANSFERASE ; AMINO-ACID-METABOLISM ; OXIDATIVE STRESS ; PLASMA HOMOCYSTEINE ; HYDROGEN-SULFIDE ; DNA METHYLATION ; GENE-EXPRESSION ; ADENOSYLHOMOCYSTEINE HYDROLASE ; ADENOSYLMETHIONINE METABOLISM |
| 资助项目 | Shanghai Committee of Science and Technology, China[20ZR1468300] ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences[SIMM2004KF-15] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000800008900003 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301471]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wu, Yanwei; Tang, Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Immunopharmacol, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Haoyu,Wu, Yanwei,Tang, Wei. Methionine cycle in nonalcoholic fatty liver disease and its potential applications[J]. BIOCHEMICAL PHARMACOLOGY,2022,200:17. |
| APA | Wang, Haoyu,Wu, Yanwei,&Tang, Wei.(2022).Methionine cycle in nonalcoholic fatty liver disease and its potential applications.BIOCHEMICAL PHARMACOLOGY,200,17. |
| MLA | Wang, Haoyu,et al."Methionine cycle in nonalcoholic fatty liver disease and its potential applications".BIOCHEMICAL PHARMACOLOGY 200(2022):17. |
入库方式： OAI收割
来源：上海药物研究所
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