中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Dithiocarbazate-Fe-III,-Co-III,-Ni-II, and-Zn(II)Complexes: Design,Synthesis, Structure, and Anticancer Evaluation

文献类型：期刊论文

作者Gou, Yi3; Jia, Xiaoying4; Hou, Li Xia3; Deng, Jun Gang3; Huang, Guo Jin3; Jiang, Hao Wen1,2; Yang, Feng3,4
刊名JOURNAL OF MEDICINAL CHEMISTRY
出版日期2022-05-12
卷号65期号:9页码:6677-6689
ISSN号0022-2623
DOI10.1021/acs.jmedchem.1c02186
通讯作者Gou, Yi(sanchuanok@126.com) ; Jiang, Hao Wen(haowenjiang@simm.ac.cn) ; Yang, Feng(fyang@mailbox.gxnu.edu.cn)
英文摘要Non-platinum-metal complexes show great potential as anticancer agents. Herein, a series of dithiocarbazate non-Pt-metal complexes, including [FeIII(L)2]middotClmiddot2H2O1, [CoIII(L)2]middotNO3middot2.5H2O2, [NiII(L)2]3, and [ZnII(L)2]4, have been designedand evaluated for their efficacy as antineoplastic agents. Among them, complex2exhibited higher anticancer efficacy than complexes1,3,4, andcisplatin against several cancer cell lines. Hemolysis assays revealed that complex2showed comparable hemolysis withcisplatin.In vivoanticancer evaluations showed that complex2could retard tumor xenograft growth effectively with low systemictoxicity. Further studies revealed that complex2suppressed cancer cells by triggering multiple mechanisms involving thesimultaneous inhibition of mitochondria and glycolytic bioenergetics. Overall, our study provides new insights into the anticancermechanism of Co complexes, which can be used as a good strategy to overcome theflexibility of cancer cells to chemotherapyadaptation.
WOS关键词RAY CRYSTAL-STRUCTURE ; SCHIFF-BASE ; METAL-COMPLEXES ; S-METHYLDITHIOCARBAZATE ; PLATINUM(IV) PRODRUG ; NICKEL(II) COMPLEXES ; COPPER-COMPLEXES ; CANCER ; MITOCHONDRIA ; CU(II)
资助项目National Natural Science Foundation of China[22007023] ; National Natural Science Foundation of China[22077021] ; Natural Science Foundation of Guangxi[2020GXNSFBA238003] ; Fund of Ministry of Education of China[CMEMR2017-A03] ; Plan Project of Guilin Scientific Research and Technology Development[2020011204-8]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000802633700019
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/301533]  
专题新药研究国家重点实验室
通讯作者Gou, Yi; Jiang, Hao Wen; Yang, Feng
作者单位1.UCAS, Hangzhou Inst Adv Study, Hangzhou 310000, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Guilin Med Univ, Lab Resp Dis, Affiliated Hosp, Guilin 541001, Guangxi, Peoples R China
4.Guangxi Norma Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Guangxi, Peoples R China
推荐引用方式
GB/T 7714		 Gou, Yi,Jia, Xiaoying,Hou, Li Xia,et al. Dithiocarbazate-Fe-III,-Co-III,-Ni-II, and-Zn(II)Complexes: Design,Synthesis, Structure, and Anticancer Evaluation[J]. JOURNAL OF MEDICINAL CHEMISTRY,2022,65(9):6677-6689.
APA Gou, Yi.,Jia, Xiaoying.,Hou, Li Xia.,Deng, Jun Gang.,Huang, Guo Jin.,...&Yang, Feng.(2022).Dithiocarbazate-Fe-III,-Co-III,-Ni-II, and-Zn(II)Complexes: Design,Synthesis, Structure, and Anticancer Evaluation.JOURNAL OF MEDICINAL CHEMISTRY,65(9),6677-6689.
MLA Gou, Yi,et al."Dithiocarbazate-Fe-III,-Co-III,-Ni-II, and-Zn(II)Complexes: Design,Synthesis, Structure, and Anticancer Evaluation".JOURNAL OF MEDICINAL CHEMISTRY 65.9(2022):6677-6689.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。