Redefinition to bilayer osmotic pump tablets as subterranean river system within mini-earth via three-dimensional structure mechanism
文献类型：期刊论文
| 作者 | Maharjan, Abi6,7,8; Sun, Hongyu5,8; Cao, Zeying6,8; Li, Ke4,6; Liu, Jinping3; Liu, Jun2,8; Xiao, Tiqiao4; Peng, Guanyun4; Ji, Junqiu2; York, Peter8 |
| 刊名 | ACTA PHARMACEUTICA SINICA B
 |
| 出版日期 | 2022-05-01 |
| 卷号 | 12期号:5页码:2568-2577 |
| ISSN号 | 2211-3835 |
| 关键词 | Bilayer osmotic pump tablet Synchrotron radiation micro-computedtomography Three-dimensional microstructure Release kinetics Void formation Peripheral ?roadways? Push-pull model Subterranean river model |
| DOI | 10.1016/j.apsb.2021.11.008 |
| 通讯作者 | Yin, Xianzhen(xzyin@simm.ac.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn) ; Wu, Li(wuli@simm.ac.cn) |
| 英文摘要 | Defining and visualizing the three-dimensional (3D) structures of pharmaceuticals provides a new and important tool to elucidate the phenomenal behavior and underlying mechanisms of drug delivery systems. The mechanism of drug release from complex structured dosage forms, such as bilayer osmotic pump tablets, has not been investigated widely for most solid 3D structures. In this study, bilayer osmotic pump tablets undergoing dissolution, as well as after dissolution in a desiccated solid state were examined, and visualized by synchrotron radiation micro-computed tomography (SR-mu CT). In situ formed 3D structures at different in vitro drug release states were characterized comprehensively. A distinct movement pattern of NaCl crystals from the push layer to the drug layer was observed, beneath the semi-permeable coating in the desiccated tablet samples. The 3D structures at different dissolution time revealed that the pushing upsurge in the bilayer osmotic pump tablet was directed via peripheral "roadways". Typically, different regions of the osmotic front, infiltration region, and dormant region were classified in the push layer during the dissolution of drug from tablet samples. According to the observed 3D microstructures, a "subterranean river model" for the drug release mechanism has been defined to explain the drug release mechanism. (c) 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| WOS关键词 | CONTROLLED-RELEASE KINETICS ; DRUG-DELIVERY ; IN-VITRO ; FORMULATION ; DESIGN |
| 资助项目 | National Nature Science Foun-dation of China[81803446] ; National Nature Science Foun-dation of China[81803441] ; National Nature Science Foun-dation of China[81773645] ; Key Program for International Science and Technology Cooperation Projects of China[2020YFE0201700] ; Youth Innovation Promotion Association of CAS[2018323] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES |
| WOS记录号 | WOS:000810921300009 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301564]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yin, Xianzhen; Zhang, Jiwen; Wu, Li |
| 作者单位 | 1.Tribhuvan Univ, Inst Med, Maharajgung Med Campus, Kathmandu 44606, Nepal 2.Chinese Acad Sci, Ctr MOST & Image Fus Anal, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China 3.Hefei Lifeon Medicat Grp, Hefei 230088, Peoples R China 4.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, Zhangjiang Lab, Shanghai 201204, Peoples R China 5.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Beijing 100050, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ, Yantai 264005, Peoples R China 8.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Maharjan, Abi,Sun, Hongyu,Cao, Zeying,et al. Redefinition to bilayer osmotic pump tablets as subterranean river system within mini-earth via three-dimensional structure mechanism[J]. ACTA PHARMACEUTICA SINICA B,2022,12(5):2568-2577. |
| APA | Maharjan, Abi.,Sun, Hongyu.,Cao, Zeying.,Li, Ke.,Liu, Jinping.,...&Wu, Li.(2022).Redefinition to bilayer osmotic pump tablets as subterranean river system within mini-earth via three-dimensional structure mechanism.ACTA PHARMACEUTICA SINICA B,12(5),2568-2577. |
| MLA | Maharjan, Abi,et al."Redefinition to bilayer osmotic pump tablets as subterranean river system within mini-earth via three-dimensional structure mechanism".ACTA PHARMACEUTICA SINICA B 12.5(2022):2568-2577. |
入库方式： OAI收割
来源：上海药物研究所
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