A dataset resource for clinically associated phosphosites in hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Meng, Qian2,3; Wang, Yuqiu1,3; Lu, Dayun3; Song, Nixue3; Zhou, Hu3 ; Zhu, Hongwen3
|
| 刊名 | PROTEOMICS
 |
| 出版日期 | 2022-06-22 |
| 页码 | 7 |
| 关键词 | hepatocellular carcinoma phosphosites prognosis recurrence TNM stage |
| ISSN号 | 1615-9853 |
| DOI | 10.1002/pmic.202100407 |
| 通讯作者 | Zhou, Hu(zhouhu@simm.ac.cn) ; Zhu, Hongwen(zhw@simm.ac.cn) |
| 英文摘要 | Phosphorylation is one of the most common post-translational modifications (PTMs) and is closely related to protein activity and function, playing a critical role during cancer development. Quantitative phosphoproteomic strategies have been widely used to study the underlying mechanisms of cancer progression or drug resistance. In this report, we analyzed the association of phosphosite levels originated from our previously reported proteogenomic study in hepatocellular carcinoma (HCC) with clinical parameters, including prognosis, recurrence, and Tumor-Node-Metastasis (TNM) stages. By using both the log-rank test and univariate Cox proportional hazards regression analysis, we found that the abundance levels of 1712 phosphosites were associated with prognosis and those of 393 phosphosites associated with recurrence. Besides, 692 phosphosites had different abundance levels among TNM stages (I, II, III+IV) by Analysis of Variance (ANOVA) test. Gene ontology (GO) biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using proteins with these statistically significant phosphosites. In conclusion, we provided a dataset resource for clinically associated phosphosites in HCC, which may be beneficial to liver cancer related basic research. |
| WOS关键词 | PROTEOGENOMIC CHARACTERIZATION |
| 资助项目 | Youth Innovation Promotion Association CAS[2022285] ; Yangfan Project of Shanghai Science and Technology Commission[20YF1457300] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000814395800001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301599]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Hu; Zhu, Hongwen |
| 作者单位 | 1.East China Univ Sci & Technol, Sch Bioengn, Shanghai, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Dept Pharmacol, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Materia Med, State Key Lab Drug Res, CAS Key Lab Receptor Res, Zuchongzhi Rd 555 Zhangjiang Hi Tech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Meng, Qian,Wang, Yuqiu,Lu, Dayun,et al. A dataset resource for clinically associated phosphosites in hepatocellular carcinoma[J]. PROTEOMICS,2022:7. |
| APA | Meng, Qian,Wang, Yuqiu,Lu, Dayun,Song, Nixue,Zhou, Hu,&Zhu, Hongwen.(2022).A dataset resource for clinically associated phosphosites in hepatocellular carcinoma.PROTEOMICS,7. |
| MLA | Meng, Qian,et al."A dataset resource for clinically associated phosphosites in hepatocellular carcinoma".PROTEOMICS (2022):7. |
入库方式： OAI收割
来源：上海药物研究所
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