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The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination

文献类型：期刊论文

作者Suo, Na5; He, Bingqing3,4,5; Cui, Shihao4,5; Yang, Ying3,4,5; Wang, Min5; Yuan, Qianting5; Xie, Xin1,2,3,4,5
刊名GLIA
出版日期2022-06-27
页码17
关键词GPR149 MAPK ERK pathway myelination oligodendrocyte oligodendrocyte progenitor cell remyelination
ISSN号0894-1491
DOI10.1002/glia.24233
通讯作者Xie, Xin(xxie@simm.ac.cn)
英文摘要Myelin sheath, formed by oligodendrocytes (OLs) in the central nervous system (CNS) and Schwann cells in periphery, plays a critical role in supporting neuronal functions. OLs, differentiated from oligodendrocyte precursor cells (OPCs), are important for myelination during development and myelin repair in CNS demyelinating disease. To identify mechanisms of myelin development and remyelination after myelin damage is of great clinical interest. Here we show that the orphan G protein-coupled receptor GPR149, enriched in OPCs, negatively regulate OPC to OL differentiation, myelination, as well as remyelination. The expression of GPR149 is downregulated during OPCs differentiation into OLs. GPR149 deficiency does not affect the number of OPCs, but promotes OPC to OL differentiation which results in earlier development of myelin. In cuprizone-induced demyelination model, GPR149 deficiency significantly enhances myelin regeneration. Further study indicates that GPR149 may regulate OL differentiation and myelin formation via MAPK/ERK pathway. Our study suggests that deleting or blocking GPR149 might be an intriguing way to promote myelin repair in demyelinating diseases.
WOS关键词OLIGODENDROCYTE PROGENITOR CELLS ; GROWTH-FACTOR ; SCHWANN-CELLS ; MATURE OLIGODENDROCYTES ; THERAPEUTIC TARGET ; ERK ACTIVATION ; BASIC-PROTEIN ; DIFFERENTIATION ; BRAIN ; MECHANISMS
资助项目Ministry of Science and Technology China Brain Initiative[2022ZD0204701] ; Ministry of Science and Technology China Brain Initiative[82121005] ; Chinese Academy of Sciences[E1G707R05] ; Chinese Academy of Sciences[XDA16010202] ; National Natural Science Foundation of China[82121005] ; National Natural Science Foundation of China[81730099] ; National Natural Science Foundation of China[82003723]
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000816740400001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/301608]  
专题新药研究国家重点实验室
通讯作者Xie, Xin
作者单位1.Univ Chinese Acad Sci, Sch Pharmaceut Sci & Technol, Hangzhou Inst Adv Study, Hangzhou, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
4.Univ Chinese Acad Sci, Sch Pharm, Beijing, Peoples R China
5.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Suo, Na,He, Bingqing,Cui, Shihao,et al. The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination[J]. GLIA,2022:17.
APA Suo, Na.,He, Bingqing.,Cui, Shihao.,Yang, Ying.,Wang, Min.,...&Xie, Xin.(2022).The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination.GLIA,17.
MLA Suo, Na,et al."The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination".GLIA (2022):17.

入库方式： OAI收割

来源：上海药物研究所

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