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Cell Membrane-Camouflaged Nanocarriers with Biomimetic Deformability of Erythrocytes for Ultralong Circulation and Enhanced Cancer Therapy

文献类型：期刊论文

作者Miao, Yunqiu2; Yang, Yuting2; Guo, Linmiao1,2; Chen, Mingshu2; Zhou, Xin2; Zhao, Yuge2; Nie, Di1,2; Gan, Yong1,2; Zhang, Xinxin1,2
刊名ACS NANO
出版日期2022-04-26
卷号16期号:4页码:6527-6540
关键词RBC-derived nanocarriers deformability drug delivery long circulation tumor penetration
ISSN号1936-0851
DOI10.1021/acsnano.2c00893
通讯作者Gan, Yong(ygan@simm.ac.cn) ; Zhang, Xinxin(xinxinzhang@simm.ac.cn)
英文摘要Despite considerable advancements in cell membrane-camouflaged nanocarriers to leverage natural cell functions, artificial nanocarriers that can accurately mimic both the biological and physical properties of cells are urgently needed. Herein, inspired by the important effect of the stiffness and deformability of natural red blood cells (RBCs) on their life span and flowing through narrow vessels, we report the construction of RBC membrane-camouflaged nanocarriers that can mimic RBCs at different life stages and study how the deformability of RBC-derived nanocarriers affects their biological behaviors. RBC membrane-coated elastic poly(ethylene glycol) diacrylate hydrogel nanoparticles (RBC-ENPs) simulating dynamic RBCs exhibited high immunocompatibility with minimum immunoglobulin adsorption in the surface protein corona, resulting in reduced opsonization in macrophages and ultralong circulation. Furthermore, RBC-ENPs can deform like RBCs and achieve excellent diffusion in tumor extracellular matrix, leading to improved multicellular spheroid penetration and tumor tissue accumulation. In mouse cancer models, doxorubicin-loaded RBC-ENPs demonstrated superior antitumor efficacy to the first-line chemotherapeutic drug PEGylated doxorubicin liposomes. Our work highlights that tuning the physical properties of cell membrane-derived nanocarriers may offer an alternative approach for the bionic design of nanomedicines in the future.
WOS关键词COATED NANOPARTICLES ; NANO-RHEOLOGY ; DEFORMATION ; DELIVERY
资助项目National Natural Science Foundation of China[81973250] ; National Natural Science Foundation of China[82025032] ; National Natural Science Foundation of China[82104113] ; Natural Science Foundation of Shanghai[21ZR1475800] ; National Key R&D Program of China[2020YFE0201700] ; Science and Technology Commission of Shanghai Municipality[20431900100]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000813119100001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/301611]  
专题新药研究国家重点实验室
通讯作者Gan, Yong; Zhang, Xinxin
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Miao, Yunqiu,Yang, Yuting,Guo, Linmiao,et al. Cell Membrane-Camouflaged Nanocarriers with Biomimetic Deformability of Erythrocytes for Ultralong Circulation and Enhanced Cancer Therapy[J]. ACS NANO,2022,16(4):6527-6540.
APA Miao, Yunqiu.,Yang, Yuting.,Guo, Linmiao.,Chen, Mingshu.,Zhou, Xin.,...&Zhang, Xinxin.(2022).Cell Membrane-Camouflaged Nanocarriers with Biomimetic Deformability of Erythrocytes for Ultralong Circulation and Enhanced Cancer Therapy.ACS NANO,16(4),6527-6540.
MLA Miao, Yunqiu,et al."Cell Membrane-Camouflaged Nanocarriers with Biomimetic Deformability of Erythrocytes for Ultralong Circulation and Enhanced Cancer Therapy".ACS NANO 16.4(2022):6527-6540.

入库方式： OAI收割

来源：上海药物研究所

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