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Discovery and biological evaluation of dispirocyclic and polycyclic ent-clerodane dimers from Isodon scoparius as novel inhibitors of Toll-like receptor signaling

文献类型：期刊论文

作者Li, Xing-Ren3,4; Chen, Li1,2; Hu, Kun3,4; Yan, Bing-Chao3,4; Du, Xue3,4; Li, Xiao-Nian3,4; Sun, Han-Dong3,4; He, Shi-Jun1,2; Puno, Pema-Tenzin3,4
刊名ORGANIC CHEMISTRY FRONTIERS
出版日期2022-06-14
页码11
ISSN号2052-4129
DOI10.1039/d2qo00723a
通讯作者He, Shi-Jun(heshijun@simm.ac.cn) ; Puno, Pema-Tenzin(punopematenzin@mail.kib.ac.cn)
英文摘要Scoparicacids A-C (1-3), three novel ent-clerodane dimers with unprecedented dispirocyclic 6/6/5/6/6 and hexacyclic 6/6/5/6/5/6 ring systems, were isolated from Isodon scoparius. A biomimetic synthesis of 3 was achieved using a double aldol reaction to construct a 5/6/5 ring system in one step. 2 and 3 exhibited significant immunosuppression on the proliferation of B lymphocytes evoked by TLR signaling stimulation in a dose-dependent manner and significantly abrogated the downstream pathway of TLR7 signaling in B cells.
WOS关键词DOUBLE ALDOL REACTION ; DITERPENOIDS
资助项目NSFC-Joint Foundation of Yunnan Province[U2002221] ; Second Tibetan Plateau Scientific Expedition and Research (STEP) program[2019QZKK0502] ; National Natural Science Foundation of China[81673329] ; CAS Light of West China Program ; CAS Interdisciplinary Innovation Team ; Yunnan Science Fund for Distinguished Young Scholars[2019FJ002]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000814221000001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/301617]  
专题新药研究国家重点实验室
通讯作者He, Shi-Jun; Puno, Pema-Tenzin
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式
GB/T 7714		 Li, Xing-Ren,Chen, Li,Hu, Kun,et al. Discovery and biological evaluation of dispirocyclic and polycyclic ent-clerodane dimers from Isodon scoparius as novel inhibitors of Toll-like receptor signaling[J]. ORGANIC CHEMISTRY FRONTIERS,2022:11.
APA Li, Xing-Ren.,Chen, Li.,Hu, Kun.,Yan, Bing-Chao.,Du, Xue.,...&Puno, Pema-Tenzin.(2022).Discovery and biological evaluation of dispirocyclic and polycyclic ent-clerodane dimers from Isodon scoparius as novel inhibitors of Toll-like receptor signaling.ORGANIC CHEMISTRY FRONTIERS,11.
MLA Li, Xing-Ren,et al."Discovery and biological evaluation of dispirocyclic and polycyclic ent-clerodane dimers from Isodon scoparius as novel inhibitors of Toll-like receptor signaling".ORGANIC CHEMISTRY FRONTIERS (2022):11.

入库方式： OAI收割

来源：上海药物研究所

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