中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Pitfalls in the structural elucidation of small molecules. A critical analysis of a decade of structural misassignments of marine natural products

文献类型：期刊论文

作者Shen, Shou-Mao3,4; Appendino, Giovanni2; Guo, Yue-Wei1,4
刊名NATURAL PRODUCT REPORTS
出版日期2022-06-30
页码30
ISSN号0265-0568
DOI10.1039/d2np00023g
通讯作者Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要Covering: July 2010 to August 2021 This article summarizes more than 200 cases of misassigned marine natural products reported between July 2010 and August 2021, sorting out errors according to the structural elements. Based on a comparative analysis of the original and the revised structures, major pitfalls still plaguing the structural elucidation of small molecules were identified, emphasizing the role of total synthesis, crystallography, as well as chemical- and biosynthetic logic to complement spectroscopic data. Distinct "trends" in natural product misassignment are evident between compounds of marine and plant origin, with an overall much lower incidence of "impossible" structures within misassigned marine natural products.
WOS关键词ASYMMETRIC TOTAL-SYNTHESIS ; CORAL SARCOPHYTON-TROCHELIOPHORUM ; EUNICELLIN-BASED DITERPENOIDS ; CELL-ADHESION INHIBITORS ; 1ST TOTAL-SYNTHESIS ; STRUCTURE REVISION ; ABSOLUTE-CONFIGURATION ; RED ALGA ; CHINESE MANGROVE ; A-C
资助项目National Natural Science Foundation of China[81991521] ; SKLDR/SIMM Project[SIMM2013ZZ-06]
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000818950500001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/301720]  
专题新药研究国家重点实验室
通讯作者Guo, Yue-Wei
作者单位1.Bohai Rim Adv Res Drug Discovery, Drug Discovery Shandong Lab, Yantai 264117, Shandong, Peoples R China
2.Univ Piemonte Orientale, Dipartimento Sci Farmaco, Largo Donegani 2, I-28100 Novara, Italy
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Shen, Shou-Mao,Appendino, Giovanni,Guo, Yue-Wei. Pitfalls in the structural elucidation of small molecules. A critical analysis of a decade of structural misassignments of marine natural products[J]. NATURAL PRODUCT REPORTS,2022:30.
APA Shen, Shou-Mao,Appendino, Giovanni,&Guo, Yue-Wei.(2022).Pitfalls in the structural elucidation of small molecules. A critical analysis of a decade of structural misassignments of marine natural products.NATURAL PRODUCT REPORTS,30.
MLA Shen, Shou-Mao,et al."Pitfalls in the structural elucidation of small molecules. A critical analysis of a decade of structural misassignments of marine natural products".NATURAL PRODUCT REPORTS (2022):30.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。