Optical molecular imaging and theranostics in neurological diseases based on aggregation-induced emission luminogens
文献类型：期刊论文
| 作者 | Cen, Peili7,8,9,10; Zhou, Youyou7,8,9,10; Cui, Chunyi7,8,9,10; Wei, Yen5,6; Cheng, Zhen4; Wu, Shuizhu3; Zhang, Hong1,2,7,8,9,10; Tian, Mei7,8,9,10 |
| 刊名 | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
 |
| 出版日期 | 2022-07-04 |
| 页码 | 22 |
| 关键词 | Aggregation-induced emission Fluorescence imaging Theranostics Brain vasculature Neurological diseases |
| ISSN号 | 1619-7070 |
| DOI | 10.1007/s00259-022-05894-7 |
| 通讯作者 | Zhang, Hong(hzhang21@zju.edu.cn) ; Tian, Mei(meitian@zju.edu.cn) |
| 英文摘要 | Optical molecular imaging and image-guided theranostics benefit from special and specific imaging agents, for which aggregation-induced emission luminogens (AIEgens) have been regarded as good candidates in many biomedical applications. They display a large Stokes shift, high quantum yield, good biocompatibility, and resistance to photobleaching. Neurological diseases are becoming a substantial burden on individuals and society that affect over 50 million people worldwide. It is urgently needed to explore in more detail the brain structure and function, learn more about pathological processes of neurological diseases, and develop more efficient approaches for theranostics. Many AIEgens have been successfully designed, synthesized, and further applied for molecular imaging and image-guided theranostics in neurological diseases such as cerebrovascular disease, neurodegenerative disease, and brain tumor, which help us understand more about the pathophysiological state of brain through noninvasive optical imaging approaches. Herein, we focus on representative AIEgens investigated on brain vasculature imaging and theranostics in neurological diseases including cerebrovascular disease, neurodegenerative disease, and brain tumor. Considering different imaging modalities and various therapeutic functions, AIEgens have great potential to broaden neurological research and meet urgent needs in clinical practice. It will be inspiring to develop more practical and versatile AIEgens as molecular imaging agents for preclinical and clinical use on neurological diseases. |
| WOS关键词 | BLOOD-BRAIN-BARRIER ; ORGANIC NANOPARTICLES ; PROTEIN AGGREGATION ; CELL TRACKING ; RED EMISSION ; PROBES ; AGENTS ; PET ; NANODOTS ; PROGRESS |
| 资助项目 | National Natural Science Foundation of China[21788102] ; National Natural Science Foundation of China[81725009] ; National Natural Science Foundation of China[82030049] ; National Natural Science Foundation of China[32027802] ; National Key R&D Program of China[2021YFE0108300] ; National Key R&D Program of China[2021YFA1101700] ; Fundamental Research Funds for the Central Universities[2021FZZX002-05] |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000820554800001 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301729]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Hong; Tian, Mei |
| 作者单位 | 1.Zhejiang Univ, Key Lab Biomed Engn, Minist Educ, Hangzhou 310014, Zhejiang, Peoples R China 2.Zhejiang Univ, Coll Biomed Engn & Instrument Sci, Hangzhou 310014, Zhejiang, Peoples R China 3.South China Univ Technol, Coll Mat Sci & Engn, State Key Lab Luminescent Mat & Devices, Guangdong Prov Key Lab Luminescence Mol Aggregate, Wushan Rd 381, Guangzhou 510640, Peoples R China 4.Chinese Acad Sci, Mol Imaging Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 5.Tsinghua Univ, Tsinghua Ctr Frontier Polymer Res, Beijing 100084, Peoples R China 6.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China 7.Key Lab Med Mol Imaging Zhejiang Prov, Hangzhou 31009, Zhejiang, Peoples R China 8.Zhejiang Univ, Inst Nucl Med & Mol Imaging, Hangzhou 31009, Zhejiang, Peoples R China 9.Zhejiang Univ, PET Ctr, Affiliated Hosp 2, Sch Med, Hangzhou 31009, Zhejiang, Peoples R China 10.Zhejiang Univ, Dept Nucl Med, Affiliated Hosp 2, Sch Med, Hangzhou 31009, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cen, Peili,Zhou, Youyou,Cui, Chunyi,et al. Optical molecular imaging and theranostics in neurological diseases based on aggregation-induced emission luminogens[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2022:22. |
| APA | Cen, Peili.,Zhou, Youyou.,Cui, Chunyi.,Wei, Yen.,Cheng, Zhen.,...&Tian, Mei.(2022).Optical molecular imaging and theranostics in neurological diseases based on aggregation-induced emission luminogens.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,22. |
| MLA | Cen, Peili,et al."Optical molecular imaging and theranostics in neurological diseases based on aggregation-induced emission luminogens".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022):22. |
入库方式： OAI收割
来源：上海药物研究所
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