Indoles Oxidative Ring-Opening/Cyclization Cascade with the 1,2-Diaminoarenes: Direct Synthesis of 2-Aryl-3-(2-aminoaryl)quinoxalines br
文献类型：期刊论文
| 作者 | Yan, Jianwei2; Zheng, Linxia2; Wang, Jiangfei2; Liu, Xiaomin2; Hu, Youhong1
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2022-05-06 |
| 卷号 | 87期号:9页码:6347-6351 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.1c03120 |
| 通讯作者 | Yan, Jianwei(jwyansimm@163.com) |
| 英文摘要 | A mild oxidative sequential tandem reaction wasdeveloped to rapidly generate 2-aryl-3-(2-aminoaryl) quinoxalines.This method exploited 2-substituted indoles as substrate to formquinoxalines in a one-pot reaction. The key to this tandem reactionwas the formation of 3-iodoindoles, which underwent Kornblum-type oxidation with DMSO to generate active imine 2-substitued3H-indol-3-ones. The active imines were captured in situ by 1,2-diaminobenzenes to construct diverse quinoxalines. Thetransformation can be accomplished at room temperature with excellent functional group tolerance |
| WOS关键词 | DIELS-ALDER REACTION ; CYCLIC C-ACYLIMINES ; QUINOXALINE DERIVATIVES ; BIOLOGICAL EVALUATION ; MANNICH REACTION ; INHIBITORS ; ACCESS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000818662400076 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301732]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yan, Jianwei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Jianwei,Zheng, Linxia,Wang, Jiangfei,et al. Indoles Oxidative Ring-Opening/Cyclization Cascade with the 1,2-Diaminoarenes: Direct Synthesis of 2-Aryl-3-(2-aminoaryl)quinoxalines br[J]. JOURNAL OF ORGANIC CHEMISTRY,2022,87(9):6347-6351. |
| APA | Yan, Jianwei,Zheng, Linxia,Wang, Jiangfei,Liu, Xiaomin,&Hu, Youhong.(2022).Indoles Oxidative Ring-Opening/Cyclization Cascade with the 1,2-Diaminoarenes: Direct Synthesis of 2-Aryl-3-(2-aminoaryl)quinoxalines br.JOURNAL OF ORGANIC CHEMISTRY,87(9),6347-6351. |
| MLA | Yan, Jianwei,et al."Indoles Oxidative Ring-Opening/Cyclization Cascade with the 1,2-Diaminoarenes: Direct Synthesis of 2-Aryl-3-(2-aminoaryl)quinoxalines br".JOURNAL OF ORGANIC CHEMISTRY 87.9(2022):6347-6351. |
入库方式： OAI收割
来源：上海药物研究所
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