中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
The Effects of a Transgelin-2 Agonist Administered at Different Times in a Mouse Model of Airway Hyperresponsiveness

文献类型：期刊论文

作者Yuan, Hong-Kai2; Lu, Jin2; Wang, Xue-Ling2; Lv, Zhi-Ying2; Li, Bo1; Zhu, Weiliang1; Yang, Yong-Qing2; Yin, Lei-Miao2
刊名FRONTIERS IN PHARMACOLOGY
出版日期2022-06-16
卷号13页码:8
关键词transgelin-2 agonist TSG12 administration time asthma airway hyperresponsiveness
DOI10.3389/fphar.2022.873612
通讯作者Yang, Yong-Qing(yyq@shutcm.edu.cn) ; Yin, Lei-Miao(collegeylm@shutcm.edu.cn)
英文摘要Airway hyperresponsiveness (AHR) is one of the most important features of asthma. Our previous study showed that inhaled transgelin-2 agonist, TSG12, effectively reduced pulmonary resistance in a mouse model of asthma in a dose-dependent manner. However, the optimal administration time of TSG12 to reduce AHR and the pharmacological effects are still unclear. In this study, the effects of TSG12 inhalation before and during AHR occurrence were examined. The results showed that the pulmonary resistance was reduced by 57% and the dynamic compliance was increased by 46% in the TSG12 Mch group (atomize TSG12 10 min before methacholine, p < 0.05 vs. model). The pulmonary resistance was reduced by 61% and the dynamic compliance was increased by 47% in the TSG12 + Mch group (atomize TSG12 and methacholine together, p < 0.05 vs. model). Quantitative real-time PCR showed that the gene expression levels of transgelin-2, myosin phosphatase target subunit-1, and myosin light chain were up-regulated by 6.4-, 1.9-, and 2.8-fold, respectively, in the TSG12 Mch group. The gene expression levels of transgelin-2, myosin phosphatase target subunit-1, and myosin light chain were up-regulated by 3.2-, 1.4-, and 1.9-fold, respectively, in the TSG12 + Mch group. The results suggested that TSG12 effectively reduces pulmonary resistance when TSG12 inhalation occurred both before and during AHR occurrence. Gene expression levels of transgelin-2 and myosin light chain were significantly up-regulated when TSG12 inhalation occurred before AHR occurrence. This study may provide a basis for the administration time of TSG12 for asthma treatment in the future.
WOS关键词ALLERGIC-ASTHMA ; METHACHOLINE ; ADULTS ; LUNG
资助项目National Natural Science Foundation of China[81922076] ; National Natural Science Foundation of China[81873373] ; National Natural Science Foundation of China[81973951] ; National Natural Science Foundation of China[81872797]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000819163300001
出版者FRONTIERS MEDIA SA
源URL[http://119.78.100.183/handle/2S10ELR8/301738]  
专题新药研究国家重点实验室
通讯作者Yang, Yong-Qing; Yin, Lei-Miao
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Receptor Res,State Key Lab Drug Res, Shanghai, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Yueyang Hosp, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Yuan, Hong-Kai,Lu, Jin,Wang, Xue-Ling,et al. The Effects of a Transgelin-2 Agonist Administered at Different Times in a Mouse Model of Airway Hyperresponsiveness[J]. FRONTIERS IN PHARMACOLOGY,2022,13:8.
APA Yuan, Hong-Kai.,Lu, Jin.,Wang, Xue-Ling.,Lv, Zhi-Ying.,Li, Bo.,...&Yin, Lei-Miao.(2022).The Effects of a Transgelin-2 Agonist Administered at Different Times in a Mouse Model of Airway Hyperresponsiveness.FRONTIERS IN PHARMACOLOGY,13,8.
MLA Yuan, Hong-Kai,et al."The Effects of a Transgelin-2 Agonist Administered at Different Times in a Mouse Model of Airway Hyperresponsiveness".FRONTIERS IN PHARMACOLOGY 13(2022):8.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。