Dolabrane-Type Diterpenoids with Immunosuppressive Activity from Koilodepas hainanense
文献类型：期刊论文
| 作者 | Ren, Yu3,4; Tong, Xiao3,4; Zhao, Ye2,3; He, Shi-Jun3 ; Fan, Yao-Yue1,3,4; Yue, Jian-Min1,3
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2022-06-24 |
| 卷号 | 85期号:6页码:1581-1590 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.2c00204 |
| 通讯作者 | Fan, Yao-Yue(s040500290@126.com) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Thirteen new dolabrane-type diterpenoids, koilodenoids A-M (1-13), including a chlorinated congener (2), along with six known analogues, were isolated from Koilodepas hainanense. The structures were determined by analysis of spectroscopic data, ECD spectra, and X-ray crystallographic studies. The absolute configuration of C-15 in the 15,16-diol unit of compounds 4 and 5 was established by using the dimolybdenum tetraacetate [Mo-2(AcO)(4)]-induced ECD method. Compounds 4, 7, 16, 17, and 19 showed moderate to significant immunosuppressive activities against the proliferation of T and B lymphocytes in vitro, with compound 16 being the most potent (IC50 0.86 and 0.29 mu M, respectively). |
| WOS关键词 | A-C ; CONSTITUENTS ; ALKALOIDS ; MANGROVE |
| 资助项目 | National Natural Science Foundation of China[81861138045] ; National Natural Science Foundation of China[82122062] ; CAMS Innovation Fund for Medical Sciences[2019-I2M-5-080] ; Youth Innovation Promotion Association CAS ; Biological Resources Program (CAS)[KFJ-BRP-008] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000818084500001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301741]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Fan, Yao-Yue; Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Med Sci, Res Units Discovery New Drug Lead Mol, Shanghai 201203, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Yu,Tong, Xiao,Zhao, Ye,et al. Dolabrane-Type Diterpenoids with Immunosuppressive Activity from Koilodepas hainanense[J]. JOURNAL OF NATURAL PRODUCTS,2022,85(6):1581-1590. |
| APA | Ren, Yu,Tong, Xiao,Zhao, Ye,He, Shi-Jun,Fan, Yao-Yue,&Yue, Jian-Min.(2022).Dolabrane-Type Diterpenoids with Immunosuppressive Activity from Koilodepas hainanense.JOURNAL OF NATURAL PRODUCTS,85(6),1581-1590. |
| MLA | Ren, Yu,et al."Dolabrane-Type Diterpenoids with Immunosuppressive Activity from Koilodepas hainanense".JOURNAL OF NATURAL PRODUCTS 85.6(2022):1581-1590. |
入库方式： OAI收割
来源：上海药物研究所
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