Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance
文献类型：期刊论文
| 作者 | Ji, Aiyan4; Lou, Hongyue4; Qu, Chunrong4; Lu, Wanglong4; Hao, Yifan3; Li, Jiafeng4; Wu, Yuyang2,4; Chang, Tonghang2,4; Chen, Hao2,4; Cheng, Zhen1,2,4 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2022-07-02 |
| 卷号 | 13期号:1页码:13 |
| DOI | 10.1038/s41467-022-31521-y |
| 通讯作者 | Chen, Hao(haoc@simm.ac.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | Small molecule NIR-II fluorophores are of interest for a range of applications but can suffer from chemical and photostability issues. Here, the authors report on the development of an acceptor molecule with improved stability in alkaline conditions expanding the range of possible applications. It is highly important and challenging to develop donor-acceptor-donor structured small-molecule second near-infrared window (NIR-II) dyes with excellent properties such as water-solubility and chem/photostability. Here, we discovery an electron acceptor, 6,7-di(thiophen-2-yl)-[1,2,5]thiadiazolo[3,4-g]quinoxaline (TQT) with highest stability in alkaline conditions, compared with conventional NIR-II building block benzobisthiadiazole (BBT) and 6,7-diphenyl-[1,2,5] thiadiazolo[3,4-g]quinoxaline (PTQ). The sulfonated hydrophilic dye, FT-TQT, is further synthesized with 2.13-fold increased quantum yield than its counterpart FT-BBT with BBT as acceptor. FT-TQT complexed with FBS is also prepared and displays a 16-fold increase in fluorescence intensity compared to FT-TQT alone. It demonstrates real-time cerebral and tumor vessel imaging capability with mu m-scale resolution. Dynamic monitoring of tumor vascular disruption after drug treatment is achieved by NIR-II fluorescent imaging. Overall, TQT is an efficient electron acceptor for designing innovative NIR-II dyes. The acceptor engineering strategy provides a promising approach to design next generation of NIR-II fluorophores which open new biomedical applications. |
| WOS关键词 | FIELD-EFFECT TRANSISTORS ; IN-VIVO ; MOLECULAR FLUOROPHORES ; LIVER-TUMOR ; FLUORESCENCE ; DONOR ; DESIGN ; PHOTOLUMINESCENCE ; CHROMOPHORES ; BINDING |
| 资助项目 | National Science and Technology Innovation 2030 Major Project of China[2021ZD0203900] ; Shanghai Municipal Science and Technology Major Project ; National Natural Science Foundation of China[82071976] ; National Natural Science Foundation of China[81901799] ; Shanghai Pujiang Program[19PJ1411100] ; Lingang Laboratory[LG-QS-202206-01] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000820356400011 |
| 出版者 | NATURE PORTFOLIO |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301759]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Chen, Hao; Cheng, Zhen |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Yantai 264117, Shandong, Peoples R China 2.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Tech Phys, Shanghai 200083, Peoples R China 4.Chinese Acad Sci, Mol Imaging Ctr, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Aiyan,Lou, Hongyue,Qu, Chunrong,et al. Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance[J]. NATURE COMMUNICATIONS,2022,13(1):13. |
| APA | Ji, Aiyan.,Lou, Hongyue.,Qu, Chunrong.,Lu, Wanglong.,Hao, Yifan.,...&Cheng, Zhen.(2022).Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance.NATURE COMMUNICATIONS,13(1),13. |
| MLA | Ji, Aiyan,et al."Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance".NATURE COMMUNICATIONS 13.1(2022):13. |
入库方式： OAI收割
来源：上海药物研究所
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