Metal-free hypervalent iodine-promoted tandem carbonyl migration and unactivated C(Ph)-C(Alkyl) bond cleavage for quinolone scaffold synthesis
文献类型：期刊论文
| 作者 | Song, Li-Rui1,2; Li, He1; Wang, Shen-Feng1; Lin, Jian-Ping1; Huang, Bin2; Long, Ya-Qiu2 |
| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2022-06-15 |
| 页码 | 4 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/d2cc02245a |
| 通讯作者 | Huang, Bin(huangbin4637@suda.edu.cn) ; Long, Ya-Qiu(longyaqiu@suda.edu.cn) |
| 英文摘要 | An unexpected iodine(iii)-mediated C(sp(3))-C(sp(2)) bond cleavage of 3-(methylamino)-2-(2-substitutedbenzoyl)acrylates for efficient synthesis of privileged scaffold 4-quinolones was described. Notably, a wide range of alkyl groups (e.g. methyl, tert-butyl or alkyl chain) can be conveniently cleaved in this system. The detailed mechanism studies revealed that the transformation proceeded through cascade ipso-cyclization and 1,2-carbonyl migration, the smaller bond energy determined ortho C-C bond cleavage rather than C-H bond cleavage, via an enamine radical intermediate. |
| WOS关键词 | ACTIVATION ; DERIVATIVES ; ANNULATION ; ARENES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000816623000001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301803]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Huang, Bin; Long, Ya-Qiu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Soochow Univ, Sch Pharmaceut Sci, Suzhou 215123, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Li-Rui,Li, He,Wang, Shen-Feng,et al. Metal-free hypervalent iodine-promoted tandem carbonyl migration and unactivated C(Ph)-C(Alkyl) bond cleavage for quinolone scaffold synthesis[J]. CHEMICAL COMMUNICATIONS,2022:4. |
| APA | Song, Li-Rui,Li, He,Wang, Shen-Feng,Lin, Jian-Ping,Huang, Bin,&Long, Ya-Qiu.(2022).Metal-free hypervalent iodine-promoted tandem carbonyl migration and unactivated C(Ph)-C(Alkyl) bond cleavage for quinolone scaffold synthesis.CHEMICAL COMMUNICATIONS,4. |
| MLA | Song, Li-Rui,et al."Metal-free hypervalent iodine-promoted tandem carbonyl migration and unactivated C(Ph)-C(Alkyl) bond cleavage for quinolone scaffold synthesis".CHEMICAL COMMUNICATIONS (2022):4. |
入库方式： OAI收割
来源：上海药物研究所
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