Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents
文献类型：期刊论文
| 作者 | Asrorov, Akmal M.4,5,6; Muhitdinov, Bahtiyor5,6; Tu, Bin6; Mirzaakhmedov, Sharafitdin5; Wang, Huiyuan6 ; Huang, Yongzhuo1,2,3,6
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| 刊名 | MOLECULES
 |
| 出版日期 | 2022-06-01 |
| 卷号 | 27期号:12页码:35 |
| 关键词 | enzyme drugs cancer therapy trichosanthin gelonin peroxidase glucose oxidase asparaginase exotoxin diphtheria toxin |
| DOI | 10.3390/molecules27123836 |
| 通讯作者 | Wang, Huiyuan(wanghuiyuan@simm.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn) |
| 英文摘要 | Cancer is one of the most serious human diseases, causing millions of deaths worldwide annually, and, therefore, it is one of the most investigated research disciplines. Developing efficient anticancer tools includes studying the effects of different natural enzymes of plant and microbial origin on tumor cells. The development of various smart delivery systems based on enzyme drugs has been conducted for more than two decades. Some of these delivery systems have been developed to the point that they have reached clinical stages, and a few have even found application in selected cancer treatments. Various biological, chemical, and physical approaches have been utilized to enhance their efficiencies by improving their delivery and targeting. In this paper, we review advanced delivery systems for enzyme drugs for use in cancer therapy. Their structure-based functions, mechanisms of action, fused forms with other peptides in terms of targeting and penetration, and other main results from in vivo and clinical studies of these advanced delivery systems are highlighted. |
| WOS关键词 | PHASE-I TRIAL ; IMMUNOTOXIN RFB4(DSFV)-PE38 BL22 ; RIBOSOME-INACTIVATING PROTEIN ; TARGETED PSEUDOMONAS EXOTOXIN ; ADVANCED SOLID TUMORS ; PTD-MODIFIED ATTEMPTS ; GROWTH-FACTOR ALPHA ; DIPHTHERIA-TOXIN ; L-ASPARAGINASE ; GLUCOSE-OXIDASE |
| 资助项目 | CAS President's International Fellowship Initiative, Belt and Road Yong Scientist program ; National Key Research and Development Program of China (China)[2021YFE0103100] ; National Nature Science Foundation of China[8201101172] ; National Nature Science Foundation of China[81925035] ; National Nature Science Foundation of China[81521005] ; Shanghai Sci-Tech Innovation Initiative[19431903100] ; Shanghai Sci-Tech Innovation Initiative[18430740800] ; Sanofi-SIBS Yong Faculty Award |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000816551700001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301806]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Huiyuan; Huang, Yongzhuo |
| 作者单位 | 1.Natl Med Prod Adm, Key Lab Qual Res & Evaluat Pharmaceut Excipients, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Zhongshan 528437, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Ajou Univ Tashkent, Sci Dept, Tashkent 100204, Uzbekistan 5.Uzbek Acad Sci, Inst Bioorgan Chem, Tashkent 100125, Uzbekistan 6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Asrorov, Akmal M.,Muhitdinov, Bahtiyor,Tu, Bin,et al. Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents[J]. MOLECULES,2022,27(12):35. |
| APA | Asrorov, Akmal M.,Muhitdinov, Bahtiyor,Tu, Bin,Mirzaakhmedov, Sharafitdin,Wang, Huiyuan,&Huang, Yongzhuo.(2022).Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents.MOLECULES,27(12),35. |
| MLA | Asrorov, Akmal M.,et al."Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents".MOLECULES 27.12(2022):35. |
入库方式： OAI收割
来源：上海药物研究所
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