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Forrestiacids C and D, unprecedented triterpene-diterpene adducts from Pseudotsuga forrestii

文献类型：期刊论文

作者Zhou, Peng-Jun4,5; Zang, Yi3; Li, Cong3; Yuan, Lin2; Zeng, Huaqiang1; Li, Jia3; Hu, Jin-Feng4,5; Xiong, Juan5
刊名CHINESE CHEMICAL LETTERS
出版日期2022-09-01
卷号33期号:9页码:4264-4268
ISSN号1001-8417
关键词Forrestiacid Pseudotsuga forrestii Pinaceae Michael adduct Lipogenesis inhibitor
DOI10.1016/j.cclet.2021.12.009
通讯作者Hu, Jin-Feng(jfhu@tzc.edu.cn) ; Xiong, Juan(jxiong@fudan.edu.cn)
英文摘要Forrestiacids C (1) and D (2), a pair of C-25 epimeric triterpene-diterpene adducts were isolated from the needles and twigs of the vulnerable conifer Pseudotsuga forrestii. This unprecedented class of compounds might be generated via an intermolecular Michael addition reaction of a rearranged 6/6/5/5-fused spiro-lanostene with an abietene. Their structures were established by spectroscopic data and X-ray crystallography. The adducts showed inhibitory activities against the ATP-citrate lyase (ACL) and acetyl-CoA carboxylase 1 (ACC1), two rate-limiting enzymes in the de novo lipogenesis pathway. (C) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
WOS关键词BEMPEDOIC ACID
资助项目National Natural Science Foundation of China[21937002] ; National Natural Science Foundation of China[81773599] ; National Natural Science Foundation of China[21772025]
WOS研究方向Chemistry
语种英语
出版者ELSEVIER SCIENCE INC
WOS记录号WOS:000815137000023
源URL[http://119.78.100.183/handle/2S10ELR8/301815]  
专题新药研究国家重点实验室
通讯作者Hu, Jin-Feng; Xiong, Juan
作者单位1.Northwestern Polytech Univ, Sch Chem & Chem Engn, Frontier Res Ctr Multidisciplinary Sci, Xian 710072, Peoples R China
2.Hunan Univ Sci & Engn, Coll Chem & Bioengn, Yongzhou 425199, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Taizhou Univ, Zhejiang Prov Key Lab Plant Ecol & Conservat, Sch Pharmaceut Sci, Taizhou 318000, Peoples R China
5.Fudan Univ, Sch Pharm, Dept Nat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Peng-Jun,Zang, Yi,Li, Cong,et al. Forrestiacids C and D, unprecedented triterpene-diterpene adducts from Pseudotsuga forrestii[J]. CHINESE CHEMICAL LETTERS,2022,33(9):4264-4268.
APA Zhou, Peng-Jun.,Zang, Yi.,Li, Cong.,Yuan, Lin.,Zeng, Huaqiang.,...&Xiong, Juan.(2022).Forrestiacids C and D, unprecedented triterpene-diterpene adducts from Pseudotsuga forrestii.CHINESE CHEMICAL LETTERS,33(9),4264-4268.
MLA Zhou, Peng-Jun,et al."Forrestiacids C and D, unprecedented triterpene-diterpene adducts from Pseudotsuga forrestii".CHINESE CHEMICAL LETTERS 33.9(2022):4264-4268.

入库方式： OAI收割

来源：上海药物研究所

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