Different Immunoregulation Roles of Activin A Compared With TGF-beta
文献类型：期刊论文
| 作者 | Li, Fanglin2,3; Long, Yiru2,3; Yu, Xiaolu2,3; Tong, Yongliang2,3; Gong, Likun1,2,3
|
| 刊名 | FRONTIERS IN IMMUNOLOGY
 |
| 出版日期 | 2022-06-14 |
| 卷号 | 13页码:9 |
| 关键词 | activin A TGF-beta activin A signaling macrophages dendritic cells B cells T effector cells regulatory T cells |
| ISSN号 | 1664-3224 |
| DOI | 10.3389/fimmu.2022.921366 |
| 通讯作者 | Gong, Likun(lkgong@simm.ac.cn) |
| 英文摘要 | Activin A, a critical member of the transforming growth factor-beta (TGF-beta) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-beta, activin A also transmits signals through SMAD2/SMAD3, however, they bind to distinct receptors. Recent studies have uncovered that activin A plays a pivotal role in both innate and adaptive immune systems. Here we mainly focus its effects on activation, differentiation, proliferation and function of cells which are indispensable in the immune system and meanwhile make some comparisons with those of TGF-beta. |
| WOS关键词 | GROWTH-FACTOR-BETA ; REGULATORY T-CELLS ; MACROPHAGES IN-VITRO ; AUTOIMMUNE NEUROINFLAMMATION ; ACTIVATION ; CYTOKINE ; SUPERFAMILY ; TGF-BETA-1 ; PATHOGENICITY ; MATURATION |
| 资助项目 | Foundation of Shanghai Science and Technology Committee[22S11902100] ; Zhongshan Municipal Bureau of Science and Technology[2020SYF08] ; Department of Science and Technology of Guangdong Province[2019B090904008] ; Department of Science and Technology of Guangdong Province[2021B0909050003] |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000816976000001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301824]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Gong, Likun |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Fanglin,Long, Yiru,Yu, Xiaolu,et al. Different Immunoregulation Roles of Activin A Compared With TGF-beta[J]. FRONTIERS IN IMMUNOLOGY,2022,13:9. |
| APA | Li, Fanglin,Long, Yiru,Yu, Xiaolu,Tong, Yongliang,&Gong, Likun.(2022).Different Immunoregulation Roles of Activin A Compared With TGF-beta.FRONTIERS IN IMMUNOLOGY,13,9. |
| MLA | Li, Fanglin,et al."Different Immunoregulation Roles of Activin A Compared With TGF-beta".FRONTIERS IN IMMUNOLOGY 13(2022):9. |
入库方式： OAI收割
来源：上海药物研究所
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