Anti-hypoxia nanosized drug delivery systems improving cancer therapy
文献类型：期刊论文
| 作者 | Yan, Wenlu4,6,7; Lang, Tianqun5,6,7; Zhu, Runqi4,6,7; Zhu, Xiao4,6,7; Li, Yu3,6,7; Wu, Ting2,6,7; Yin, Qi4,5,6,7 ; Li, Yaping1,4,6,7
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| 刊名 | NANO TODAY
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| 出版日期 | 2022-02-01 |
| 卷号 | 42页码:36 |
| 关键词 | Tumor Hypoxia Nanomedicine Drug delivery Cancer therapy Synergy |
| ISSN号 | 1748-0132 |
| DOI | 10.1016/j.nantod.2022.101376 |
| 通讯作者 | Yin, Qi(qyin@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn) |
| 英文摘要 | The abnormal tumor vascular system and long distances among cells inside tumors and blood vessels lead to restricted oxygen content and diffusion impairment in the tumor tissues, which are two essential factors contributing to hypoxia. Since hypoxia is an important feature of malignant solid tumors, it is closely related to the development of tumors and resistance to therapies. Recently, various anti-hypoxia treatments based on nanosized drug delivery systems (NDDSs) have been developed to enhance the efficacy of cancer therapy, providing a feasible solution for overcoming the obstacles to cancer treatments caused by hypoxia. In this review, the latest research progress on improving cancer therapy by anti-hypoxia NDDSs based on various mechanisms, including increasing oxygen supply, reducing oxygen consumption, and inhibiting hypoxia-related signaling pathways, is summarized. On the basis of discussing the advantages and shortcomings of these strategies, we propose possible directions and perspectives on further studies and clinical translation. (C) 2022 Elsevier Ltd. All rights reserved. |
| WOS关键词 | BRAIN RADIATION-THERAPY ; EFAPROXIRAL ADMINISTERED CONCURRENT ; ENHANCED PHOTODYNAMIC THERAPY ; TUMOR HYPOXIA ; HYPERBARIC-OXYGEN ; NECK-CANCER ; INDUCIBLE FACTOR-1-ALPHA ; CHEMOTHERAPY ADJUVANT ; ENDOGENOUS MARKERS ; CELL CARCINOMA |
| 资助项目 | National Natural Science Foundation of China[81871471] ; National Natural Science Foundation of China[31930066] ; National Natural Science Foundation of China[32130058] ; National Natural Science Foundation of China[32171315] ; Natural Science Foundation of Shanghai[19ZR1479900] ; International Partnership Program of CAS[153631KYSB20190013] ; Natural Science Foundation of Shandong[ZR2019ZD25] ; Special Research Assistant Project of CAS, China Postdoctoral Science Foundation[2020M681428] ; Shanghai Post-doctoral Excellence Program[2020495] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000819834700002 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/301827]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yin, Qi; Li, Yaping |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Yantai 264000, Peoples R China 2.Nanjing Med Univ, Sch Pharm, Dept Pharmaceut, Nanjing 211116, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 4.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 5.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China 6.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 7.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Wenlu,Lang, Tianqun,Zhu, Runqi,et al. Anti-hypoxia nanosized drug delivery systems improving cancer therapy[J]. NANO TODAY,2022,42:36. |
| APA | Yan, Wenlu.,Lang, Tianqun.,Zhu, Runqi.,Zhu, Xiao.,Li, Yu.,...&Li, Yaping.(2022).Anti-hypoxia nanosized drug delivery systems improving cancer therapy.NANO TODAY,42,36. |
| MLA | Yan, Wenlu,et al."Anti-hypoxia nanosized drug delivery systems improving cancer therapy".NANO TODAY 42(2022):36. |
入库方式： OAI收割
来源：上海药物研究所
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