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Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

文献类型：期刊论文

作者Qin, Shugang6; Xiao, Wen6; Zhou, Chuanmin4,5; Pu, Qinqin4; Deng, Xin3; Lan, Lefu2; Liang, Haihua1; Song, Xiangrong6; Wu, Min4,6
刊名SIGNAL TRANSDUCTION AND TARGETED THERAPY
出版日期2022-06-25
卷号7期号:1页码:27
ISSN号2095-9907
DOI10.1038/s41392-022-01056-1
通讯作者Song, Xiangrong(songxr@scu.edu.cn) ; Wu, Min(min.wu@und.edu)
英文摘要Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive pulmonary disorder (COPD), cancer, and severe infection requiring ventilation, such as COVID-19. P. aeruginosa is also a widely-used model bacterium for all biological areas. In addition to continued, intense efforts in understanding bacterial pathogenesis of P. aeruginosa including virulence factors (LPS, quorum sensing, two-component systems, 6 type secretion systems, outer membrane vesicles (OMVs), CRISPR-Cas and their regulation), rapid progress has been made in further studying host-pathogen interaction, particularly host immune networks involving autophagy, inflammasome, non-coding RNAs, cGAS, etc. Furthermore, numerous technologic advances, such as bioinformatics, metabolomics, scRNA-seq, nanoparticles, drug screening, and phage therapy, have been used to improve our understanding of P. aeruginosa pathogenesis and host defense. Nevertheless, much remains to be uncovered about interactions between P. aeruginosa and host immune responses, including mechanisms of drug resistance by known or unannotated bacterial virulence factors as well as mammalian cell signaling pathways. The widespread use of antibiotics and the slow development of effective antimicrobials present daunting challenges and necessitate new theoretical and practical platforms to screen and develop mechanism-tested novel drugs to treat intractable infections, especially those caused by multi-drug resistance strains. Benefited from has advancing in research tools and technology, dissecting this pathogen's feature has entered into molecular and mechanistic details as well as dynamic and holistic views. Herein, we comprehensively review the progress and discuss the current status of P. aeruginosa biophysical traits, behaviors, virulence factors, invasive regulators, and host defense patterns against its infection, which point out new directions for future investigation and add to the design of novel and/or alternative therapeutics to combat this clinically significant pathogen.
WOS关键词III SECRETION SYSTEM ; HEMOLYTIC-PHOSPHOLIPASE-C ; HORIZONTAL GENE-TRANSFER ; OUTER-MEMBRANE VESICLES ; GRAM-NEGATIVE BACTERIA ; ACTIN CYTOSKELETON DISRUPTION ; SPECTRUM BETA-LACTAMASES ; QUORUM SENSING NETWORK ; GMP-AMP SYNTHASE ; NF-KAPPA-B
资助项目National Institutes of Health[R01 AI109317-06] ; National Institutes of Health[AI138203-3] ; National Institutes of Health[2022]
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
语种英语
出版者SPRINGERNATURE
WOS记录号WOS:000815634900001
源URL[http://119.78.100.183/handle/2S10ELR8/301833]  
专题新药研究国家重点实验室
通讯作者Song, Xiangrong; Wu, Min
作者单位1.Northwest Univ, Coll Life Sci, Xian 710069, Shaanxi, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.City Univ Hong Kong, Dept Biomed Sci, Hong Kong, Peoples R China
4.Univ North Dakota, Sch Med & Hlth Sci, Dept Biomed Sci, Grand Forks, ND 58203 USA
5.Wuhan Univ, Sch Publ Hlth, State Key Lab Virol, Wuhan 430071, Peoples R China
6.Sichuan Univ, West China Hosp, Dept Crit Care Med, Frontiers Sci Ctr Diseaserelated Mol Network,Stat, Chengdu, Peoples R China
推荐引用方式
GB/T 7714		 Qin, Shugang,Xiao, Wen,Zhou, Chuanmin,et al. Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2022,7(1):27.
APA Qin, Shugang.,Xiao, Wen.,Zhou, Chuanmin.,Pu, Qinqin.,Deng, Xin.,...&Wu, Min.(2022).Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics.SIGNAL TRANSDUCTION AND TARGETED THERAPY,7(1),27.
MLA Qin, Shugang,et al."Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics".SIGNAL TRANSDUCTION AND TARGETED THERAPY 7.1(2022):27.

入库方式： OAI收割

来源：上海药物研究所

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