Alterations of Dopamine Receptors and the Adaptive Changes of L-Type Calcium Channel Subtypes Regulate Cocaine-Seeking Habit in Tree Shrew
文献类型：期刊论文
| 作者 | Duan, Ying1,2; Jin, Lingtong1,2; Du, Wenjie1,2; Jin, Shubo1,2; Meng, Yiming1,2 ; Li, Yonghui1,2; Zhang, Jianjun1,2; Liang, Jing1,2; Sui, Nan1,2; Shen, Fang1,2
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| 刊名 | LIFE-BASEL
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| 出版日期 | 2022-07-01 |
| 卷号 | 12期号:7页码:16 |
| 关键词 | cocaine-seeking habit putamen DA receptors LTCCs tree shrew |
| DOI | 10.3390/life12070984 |
| 通讯作者 | Shen, Fang(shenf@psych.ac.cn) |
| 英文摘要 | The putamen (Put) is necessary for habitual actions, while the nucleus caudate (Cd) is critical for goal-directed actions. However, compared with the natural reward (such as sucrose)-seeking habit, how drug-related dysfunction or imbalance between the Put and Cd is involved in cocaine-seeking habit, which is not easy to bias behavior to goal-directed actions, is absent. Therefore, in our present study, in comparison with sucrose-habitual behavior, we evaluated the distinctive changes of the two subtypes of dopamine (DA) receptors (D1R and D2R) in cocaine-seeking habitual behavior animals. Moreover, the adaptive changes of Ca(v)1.2 and Ca(v)1.3, as prime downstream targets of D1R and D2R respectively, were also assessed. Our results showed that a similar percentage of the animals exhibited habitual seeking behavior after cocaine or sucrose variable-interval self-administration (SA) training in tree shrews. In addition, compared with animals with non-habitual behavior, animals with cocaine habitual behavior showed higher D1Rs and Ca(v)1.2 expression in the Put accompanied with lower D2Rs and Ca(v)1.3 expression in the Cd. However, after sucrose SA training, animals with habitual behavior only showed lower membrane expression of D2R in the Put than animals with non-habitual behavior. These results suggested that the upregulation of D1Rs-Ca(v)1.2 signaling may lead to hyper-excitability of the Put, and the inactivation of D2Rs-Ca(v)1.3 signaling may result in depressed activity in the Cd. This imbalance function between the Put and Cd, which causes an inability to shift between habits and goal-directed actions, may underlie the compulsive addiction habit. |
| 收录类别 | SCI |
| WOS关键词 | CONDITIONED PLACE AVERSION ; DORSAL STRIATUM ; DORSOLATERAL STRIATUM ; DORSOMEDIAL STRIATUM ; DRUG-ADDICTION ; MODULATION ; EXPRESSION ; CA(V)1.2 ; ROLES ; D2 |
| 资助项目 | Ministry of Science and Technology of the People's Republic of China[2021ZD0203800] ; National Natural Science Foundation of China[3197070674] ; National Natural Science Foundation of Beijing[7202128] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS-VPST Silk Road Science Fund 2021[GJHZ202129] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Microbiology |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000833130000001 |
| 资助机构 | Ministry of Science and Technology of the People's Republic of China ; National Natural Science Foundation of China ; National Natural Science Foundation of Beijing ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS-VPST Silk Road Science Fund 2021 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/43012]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Shen, Fang |
| 作者单位 | 1.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Ying,Jin, Lingtong,Du, Wenjie,et al. Alterations of Dopamine Receptors and the Adaptive Changes of L-Type Calcium Channel Subtypes Regulate Cocaine-Seeking Habit in Tree Shrew[J]. LIFE-BASEL,2022,12(7):16. |
| APA | Duan, Ying.,Jin, Lingtong.,Du, Wenjie.,Jin, Shubo.,Meng, Yiming.,...&Shen, Fang.(2022).Alterations of Dopamine Receptors and the Adaptive Changes of L-Type Calcium Channel Subtypes Regulate Cocaine-Seeking Habit in Tree Shrew.LIFE-BASEL,12(7),16. |
| MLA | Duan, Ying,et al."Alterations of Dopamine Receptors and the Adaptive Changes of L-Type Calcium Channel Subtypes Regulate Cocaine-Seeking Habit in Tree Shrew".LIFE-BASEL 12.7(2022):16. |
入库方式： OAI收割
来源：心理研究所
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